ID K7A4Z3_9ALTE Unreviewed; 890 AA.
AC K7A4Z3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=C427_1602 {ECO:0000313|EMBL:AGH43711.1};
OS Paraglaciecola psychrophila 170.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Paraglaciecola.
OX NCBI_TaxID=1129794 {ECO:0000313|EMBL:AGH43711.1, ECO:0000313|Proteomes:UP000011864};
RN [1] {ECO:0000313|EMBL:AGH43711.1, ECO:0000313|Proteomes:UP000011864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=170 {ECO:0000313|EMBL:AGH43711.1,
RC ECO:0000313|Proteomes:UP000011864};
RX PubMed=23640379;
RA Yin J., Chen J., Liu G., Yu Y., Song L., Wang X., Qu X.;
RT "Complete Genome Sequence of Glaciecola psychrophila Strain 170T.";
RL Genome Announc. 1:E00199-13(2013).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP003837; AGH43711.1; -; Genomic_DNA.
DR AlphaFoldDB; K7A4Z3; -.
DR STRING; 1129794.C427_1602; -.
DR KEGG; gps:C427_1602; -.
DR PATRIC; fig|1129794.4.peg.1586; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_7_3_6; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000011864; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000011864}.
FT DOMAIN 724..740
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 650..657
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 890 AA; 99706 MW; 8B1705F02F55B38E CRC64;
MLNMSRQPSD KKNKVISIMP SNNFSEQTPI SPALQTHTPM MQQYLKIKAE HPDILLFYRM
GDFYELFFDD AKKASELLDI SLTARGKSGG NAIPMAGVPY HAVENYLARL VKMGQSVAIV
EQIGDPATSK GPVDRKVQRI VTPGTVSDEA LLEDKQDNIL AAVVSVKQQS SVYFGYATLD
VTTGRFTLCE PKDAEALAAE IQRTNPVELL YPEDFAFQHI IEQRKGLRRR PQWEFDFDTA
TKQLNQQFGT KELTGFGVTA NKIGLCAAGC VMQYVKDTQR SALPHIRNIV LETESDTVLM
DAATRRNLEL TQNLSGGKEH TLASVLDNAA TPMGSRLLQR WLHRPLTNVS ILKQRQLNIK
SLLNSDYPQL QSNLKQVGDM QRVLARLALR SARPRDFVRL RQAFMLLPDI QGFITDQSAE
SANKGLMQLA NDISQFPSFA DLLNNAIEEA PPVLIRDGGV IKTGYNPELD ELRALSKGAT
DYLDELEQRE KDRTGISTLK VGYNRVHGYF IEVSRSYADK VPADYVRRQT LKNNERYIIQ
ELKEHEDKVL TSQSKSLALE KRLYDELFDI LMPELANLMQ SADAIAELDV LTNLAERAET
LNYHCPELSE KSGIHFEQGR HPVVEHVMKT PFIANPIAVN PHRRMLVITG PNMGGKSTYM
RQTALIVLMA YMGSFIPAEN AQIGPIDRIF TRIGASDDLA SGRSTFMVEM TETANILNNA
TANSLVLMDE IGRGTSTYDG LSLAWACAEY LALKIQSYTL FATHYFELTQ LAEDLPELAN
VHLDAVEHEE TIRFMHAVQE GAANKSYGLQ VAQLAGVPRS VIQKAKHKLA ELENQPVSNN
QPQVRQEQQL NLLNLVDDLR LCLKQINPDD LTPKQALEYL YQLKTLAAQD
//
