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Database: UniProt
Entry: K7A5N8_9ALTE
LinkDB: K7A5N8_9ALTE
Original site: K7A5N8_9ALTE 
ID   K7A5N8_9ALTE            Unreviewed;       698 AA.
AC   K7A5N8;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   08-MAY-2019, entry version 46.
DE   SubName: Full=Fatty oxidation complex subunit alpha {ECO:0000313|EMBL:AGH42407.1};
GN   Name=fadN {ECO:0000313|EMBL:AGH42407.1};
GN   ORFNames=C427_0297 {ECO:0000313|EMBL:AGH42407.1};
OS   Paraglaciecola psychrophila 170.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Alteromonadaceae; Paraglaciecola.
OX   NCBI_TaxID=1129794 {ECO:0000313|EMBL:AGH42407.1, ECO:0000313|Proteomes:UP000011864};
RN   [1] {ECO:0000313|EMBL:AGH42407.1, ECO:0000313|Proteomes:UP000011864}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=170 {ECO:0000313|EMBL:AGH42407.1};
RX   PubMed=23640379;
RA   Yin J., Chen J., Liu G., Yu Y., Song L., Wang X., Qu X.;
RT   "Complete Genome Sequence of Glaciecola psychrophila Strain 170T.";
RL   Genome Announc. 1:217-225(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:58856; EC=4.2.1.17;
CC         Evidence={ECO:0000256|SAAS:SAAS01133165};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 4-saturated-(3S)-hydroxyacyl-CoA = a (3E)-enoyl-CoA +
CC         H2O; Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521,
CC         ChEBI:CHEBI:137480; EC=4.2.1.17;
CC         Evidence={ECO:0000256|SAAS:SAAS01123900};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC       hydratase/isomerase family. {ECO:0000256|SAAS:SAAS00546642}.
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DR   EMBL; CP003837; AGH42407.1; -; Genomic_DNA.
DR   RefSeq; WP_007637947.1; NZ_BAES01000041.1.
DR   STRING; 1129794.C427_0297; -.
DR   EnsemblBacteria; AGH42407; AGH42407; C427_0297.
DR   KEGG; gps:C427_0297; -.
DR   PATRIC; fig|1129794.4.peg.292; -.
DR   KO; K07516; -.
DR   OrthoDB; 977512at2; -.
DR   BioCyc; GPSY1129794:G1HFR-258-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000011864; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011864};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Isomerase {ECO:0000256|SAAS:SAAS00546511};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   Lyase {ECO:0000256|SAAS:SAAS00999128};
KW   Multifunctional enzyme {ECO:0000256|SAAS:SAAS00999134};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011864}.
FT   DOMAIN      295    468       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      475    568       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      604    690       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   698 AA;  75757 MW;  72DED2AB67B0E6B1 CRC64;
     MSVVSYQLEG DIGVIRLNNP PVNALSHALR SGIQDAVTQA QDDASLALVL MCEGRTFIAG
     ADISEFGKPP MLPSLPELLI VLEASKKPII AAIHGTALGG GLETALACHY RCALPSAQVG
     LPEVKLGLLP GAGGTQRVPR LTGVKAALDL MTTGAPIAAA QALNIGLIDK VVEGDLLSAA
     LDFANEVIAQ GAELKRVSDL EVDKTTASAE FFAEYRKTLS KRLRGQEAPH RIVECIEAAL
     NTPFDEGLKV ERRLFVECMQ SSQSGALQHM FFAERMSSKV KDLPKDTQLK DIKRVGIIGG
     GLMGGGIAMN FVNVGIPVTL LEISQEALQR GKDLIAKNYA MTVSKGKLTV ELATQRQDMI
     TGTTDYNDLA DMDLVIEAVF ENLDIKKQVF AKLDNVCKQG AILASNTSYQ DVNLIAQSTS
     RPQDVIGLHF FSPANVMKLL EIVRGDETSD EVVATSMAIA KSIKKVPALS RVCYGFIGNR
     MLRHYAREAQ LCLLEGSTPQ NIDAVMQKFG MAMGPLAVGD LAGIDIGYKA REGLTDEQKG
     DVRTYCIADA LYEMGRLGQK TGAGYYQYDP ETRQRSVDPV VMEVIEAQAK KRGVERKVIS
     DKTILDRLTF ALINEGFKIL EEGIAQRPSD IDVVYAFGYG FPAYRGGPMF YADTIGLEKI
     YHTVCEFADT YGEEFWQPAA LLKQLVEEGK TLTQWANS
//
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