ID K7AWZ3_PANTR Unreviewed; 798 AA.
AC K7AWZ3; A0A2J8IML0;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
GN Name=AMPD2 {ECO:0000313|EMBL:JAA12428.1,
GN ECO:0000313|Ensembl:ENSPTRP00000064035.1, ECO:0000313|VGNC:VGNC:84};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA12428.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000064035.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA12428.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA03504.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA42713.1}, Skin {ECO:0000313|EMBL:JAA26369.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA12428.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000064035.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|PIRNR:PIRNR001251};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC ECO:0000256|PIRNR:PIRNR001251}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04064486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01007834; JAA03504.1; -; mRNA.
DR EMBL; GABF01009717; JAA12428.1; -; mRNA.
DR EMBL; GABD01006731; JAA26369.1; -; mRNA.
DR EMBL; GABE01002026; JAA42713.1; -; mRNA.
DR RefSeq; XP_016779613.1; XM_016924124.1.
DR Ensembl; ENSPTRT00000093032.1; ENSPTRP00000064035.1; ENSPTRG00000001057.7.
DR GeneID; 469403; -.
DR CTD; 271; -.
DR VGNC; VGNC:84; AMPD2.
DR GeneTree; ENSGT00950000183011; -.
DR OrthoDB; 20951at2759; -.
DR UniPathway; UPA00591; UER00663.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000001057; Expressed in superior frontal gyrus and 21 other cell types or tissues.
DR GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd01319; AMPD; 1.
DR Gene3D; 4.10.800.20; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR006650; A/AMP_deam_AS.
DR InterPro; IPR006329; AMPD.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01429; AMP_deaminase; 1.
DR PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR PANTHER; PTHR11359:SF3; AMP DEAMINASE 2; 1.
DR Pfam; PF19326; AMP_deaminase; 1.
DR PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS00485; A_DEAMINASE; 1.
PE 2: Evidence at transcript level;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR001251};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 798 AA; 92041 MW; A31876E9F8CC8F9B CRC64;
MASEARGGLG APPLQSARSL PGPAPCLKHF PLDLRTSMDG KCKEIAEELF TRSLAESELR
SAPYEFPEES PIEQLEERRQ RLERQISQDV KLEPDILLRA KQDFLKTDSD SDLQLYKEQG
EGQGDRSLRE RDVLEREFQR VTISGEEKCG VPFTDLLDAA KSVVRALFIR EKYMALSLQS
FCPTTRRYLQ QLAEKPLETR TYEQGPDTPV SADAPVHPPA LEQHPYEHCE PSTMPGDLGL
GLRMVRGVVH VYTRREPDEH CSEVELPYPD LQEFVADVNV LMALIINGPI KSFCYRRLQY
LSSKFQMHVL LNEMKELAAQ KKVPHRDFYN IRKVDTHIHA SSCMNQKHLL RFIKRAMKRH
LEEIVHVEQG REQTLREVFE SMNLTAYDLS VDTLDVHADR NTFHRFDKFN AKYNPIGESV
LREIFIKTDN RVSGKYFAHI IKEVMSDLEE SKYQNAELRL SIYGRSRDEW DKLARWAVMH
RVHSPNVRWL VQVPRLFDVY RTKGQLANFQ EMLENIFLPL FEATVHPASH PELHLFLEHV
DGFDSVDDES KPENHVFNLE SPLPEAWVEE DNPPYAYYLY YTFANMAMLN HLRRQRGFHT
FVLRPHCGEA GPIHHLVSAF MLAENISHGL LLRKAPVLQY LYYLAQIGIA MSPLSNNSLF
LSYHRNPLPE YLSRGLMVSL STDDPLQFHF TKEPLMEEYS IATQVWKLSS CDMCELARNS
VLMSGFSHKV KSHWLGPNYT KEGPEGNDIR RTNVPDIRVG YRYETLCQEL ALITQAVQSE
MLETIPEEAG IAMSPGPQ
//
