ID K7AZ13_PANTR Unreviewed; 1058 AA.
AC K7AZ13; H2QR85;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Ankyrin repeat domain 32 {ECO:0000313|EMBL:JAA13148.1};
DE SubName: Full=SMC5-SMC6 complex localization factor 1 {ECO:0000313|Ensembl:ENSPTRP00000029231.7};
GN Name=SLF1 {ECO:0000313|Ensembl:ENSPTRP00000029231.7,
GN ECO:0000313|VGNC:VGNC:4165};
GN Synonyms=ANKRD32 {ECO:0000313|EMBL:JAA13148.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA13148.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000029231.7, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA13148.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA37925.1}, and Smooth
RC vascular {ECO:0000313|EMBL:JAA13148.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000029231.7}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04061992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABF01008997; JAA13148.1; -; mRNA.
DR EMBL; GABE01006814; JAA37925.1; -; mRNA.
DR RefSeq; XP_009447122.2; XM_009448847.2.
DR PaxDb; 9598-ENSPTRP00000029231; -.
DR Ensembl; ENSPTRT00000031642.7; ENSPTRP00000029231.7; ENSPTRG00000017079.7.
DR KEGG; ptr:461750; -.
DR VGNC; VGNC:4165; SLF1.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG1929; Eukaryota.
DR GeneTree; ENSGT00940000158953; -.
DR OMA; EMKNHDE; -.
DR OrthoDB; 2478587at2759; -.
DR TreeFam; TF329705; -.
DR Proteomes; UP000002277; Chromosome 5.
DR Bgee; ENSPTRG00000017079; Expressed in bone marrow and 20 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0042405; C:nuclear inclusion body; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000786; C:nucleosome; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IBA:GO_Central.
DR GO; GO:2000781; P:positive regulation of double-strand break repair; IEA:Ensembl.
DR GO; GO:0034184; P:positive regulation of maintenance of mitotic sister chromatid cohesion; IEA:Ensembl.
DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:1990166; P:protein localization to site of double-strand break; IBA:GO_Central.
DR CDD; cd17750; BRCT_SLF1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR042479; Slf1.
DR PANTHER; PTHR46677; SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1; 1.
DR PANTHER; PTHR46677:SF1; SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF16770; RTT107_BRCT_5; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00292; BRCT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 2..80
FT /note="BRCT"
FT /evidence="ECO:0000259|SMART:SM00292"
FT DOMAIN 121..199
FT /note="BRCT"
FT /evidence="ECO:0000259|SMART:SM00292"
FT REPEAT 806..839
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 840..872
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 874..906
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ SEQUENCE 1058 AA; 121193 MW; D2AC2C4F97D3A6EC CRC64;
MEDGAPKHII QMTGFKMEEK EALVKLLLKL DCTFIKSEKY KNCTHLIAER LCKSEKFLAA
CAAGKWILTK DYIIHSAKSG RWLDETIYEW GYKIEKDSRY SPQMQSAPKR WREELKRTGA
PGAFHRWKVV LLIRTDKRSD SLIRVLEAGK ANVILPKSSP SGITHVIASN ARIKAEKEKD
NFKAPFYPIQ YLGDFLLEKE IQNDEDSQTN SVWTEHSNEE TNKDFRKDAG FLEMKGALRE
TMYRTQKEMQ NHEDVNVGSI LIQHHKKEKF SGSSKDLKFV KMRNTFGRHT YENQKEIKKK
DEDIQRSYTL RRKRKKEKES NCKKDVEHEK IKSTLRRHIY NRDQKEMKNS IFAEYAKESK
AMAIKTDVDV VEIKNTLRKH IYRAQAVRYN CIRIDKQPVY NVEVKNAEFP RGVLNLIESL
IEGQFFKEAI EELSTLQAHY IPPVCVLHAL LENVLQDNID TFSGRYFHIL SALLHLHPPW
KSPAMSRYYL ELFQCPTCMK GAWSLVEVLI RSCLFDESFC HQISENIGSK VLHLMLLKFF
FNLVESEVQH LSQKLYDWSD SQNLKITGKA MLLEIFWSGS ETSGLLTKPV NMLLEWTIYS
HKEKFKSNDV FKHELAYLLA GILGAAIDYW IFLGLKMGRN VMRHMSDDLG SYVSLSCDDF
SSQELEIFIC SFSSSWLQMF VAEAVFKKLC LQSSGSVSSE PLSLQKMVYS YLPALGKTGV
LGSGKIQVSK KIGQRPCFDS QRALLMLNGT KQKQVEGLPE LPDLNLAKCS SSLKKLKKKS
EGELSCSKEN CPSVVKKMNF HKTNLKGETA LHRACINNQV EKLILLLSLP GIDINVKDNA
GWTPLHEACN YGNTVCVQEI LQRCPEVDLL TQVDGVTPLH DALSNGHVEI GKLLLQHGGP
VLLQQRNAKG ELPLDYVVSP QIKEELFAIT KIEDTVENFH AQAEKHFHYQ QLEFGSFLLS
RMLLNFCSIF DLSSEFILAS KGLTHLNELL MACKSHKETT SVHTDWLLDL YAGNIKTLQK
LPHILKELPE NLKVCPGVHT EALMVTLEMM CRSVMEFS
//
