ID K7B188_PANTR Unreviewed; 158 AA.
AC K7B188; A0A2J8Q8R7; H2QV48;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=AP complex subunit sigma {ECO:0000256|PIRNR:PIRNR015588};
GN Name=AP1S1 {ECO:0000313|EMBL:JAA05800.1,
GN ECO:0000313|Ensembl:ENSPTRP00000033422.5, ECO:0000313|VGNC:VGNC:7211};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA05800.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000033422.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA05800.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA05800.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA34532.1}, Skin {ECO:0000313|EMBL:JAA28951.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA19217.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000033422.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}. Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004600}.
CC -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC {ECO:0000256|ARBA:ARBA00006972, ECO:0000256|PIRNR:PIRNR015588}.
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DR EMBL; AC187615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01005538; JAA05800.1; -; mRNA.
DR EMBL; GABF01002928; JAA19217.1; -; mRNA.
DR EMBL; GABD01004149; JAA28951.1; -; mRNA.
DR EMBL; GABE01010207; JAA34532.1; -; mRNA.
DR RefSeq; XP_001153078.2; XM_001153078.4.
DR STRING; 9598.ENSPTRP00000033422; -.
DR PaxDb; 9598-ENSPTRP00000033422; -.
DR Ensembl; ENSPTRT00000036154.5; ENSPTRP00000033422.5; ENSPTRG00000019520.5.
DR GeneID; 740971; -.
DR KEGG; ptr:740971; -.
DR CTD; 1174; -.
DR VGNC; VGNC:7211; AP1S1.
DR eggNOG; KOG0934; Eukaryota.
DR GeneTree; ENSGT00970000193372; -.
DR OMA; LAKWYAT; -.
DR OrthoDB; 998051at2759; -.
DR TreeFam; TF312921; -.
DR Proteomes; UP000002277; Chromosome 7.
DR Bgee; ENSPTRG00000019520; Expressed in prefrontal cortex and 21 other cell types or tissues.
DR GO; GO:0030121; C:AP-1 adaptor complex; IEA:InterPro.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0035615; F:clathrin adaptor activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR CDD; cd14831; AP1_sigma; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR InterPro; IPR044733; AP1_sigma.
DR InterPro; IPR016635; AP_complex_ssu.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR000804; Clathrin_sm-chain_CS.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR PANTHER; PTHR11753; ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY; 1.
DR PANTHER; PTHR11753:SF14; AP-1 COMPLEX SUBUNIT SIGMA-1A; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR PIRSF; PIRSF015588; AP_complex_sigma; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|PIRNR:PIRNR015588};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR015588};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transport {ECO:0000256|PIRNR:PIRNR015588}.
FT DOMAIN 1..141
FT /note="AP complex mu/sigma subunit"
FT /evidence="ECO:0000259|Pfam:PF01217"
SQ SEQUENCE 158 AA; 18733 MW; E461937790406D8B CRC64;
MMRFMLLFSR QGKLRLQKWY LATSDKERKK MVRELMQVVL ARKPKMCSFL EWRDLKVVYK
RYASLYFCCA IEGQDNELIT LELIHRYVEL LDKYFGSVCE LDIIFNFEKA YFILDEFLMG
GDVQDTSKKS VLKAIEQADL LQEEDESPRS VLEEMGLA
//
