ID K7B5Z1_PANTR Unreviewed; 464 AA.
AC K7B5Z1; A0A2J8JXS3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Sushi repeat containing protein X-linked {ECO:0000313|Ensembl:ENSPTRP00000066429.1};
DE SubName: Full=Sushi-repeat containing protein, X-linked {ECO:0000313|EMBL:JAA25646.1};
GN Name=SRPX {ECO:0000313|EMBL:JAA25646.1,
GN ECO:0000313|Ensembl:ENSPTRP00000066429.1, ECO:0000313|VGNC:VGNC:8307};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA25646.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000066429.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA25646.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA08928.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA37561.1}, Skin {ECO:0000313|EMBL:JAA25646.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA16550.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000066429.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; AACZ04032787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC193046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01002410; JAA08928.1; -; mRNA.
DR EMBL; GABF01005595; JAA16550.1; -; mRNA.
DR EMBL; GABD01007454; JAA25646.1; -; mRNA.
DR EMBL; GABE01007178; JAA37561.1; -; mRNA.
DR RefSeq; XP_016799387.1; XM_016943898.1.
DR PaxDb; 9598-ENSPTRP00000037386; -.
DR Ensembl; ENSPTRT00000078302.1; ENSPTRP00000066429.1; ENSPTRG00000021796.6.
DR GeneID; 465567; -.
DR KEGG; ptr:465567; -.
DR CTD; 8406; -.
DR VGNC; VGNC:8307; SRPX.
DR GeneTree; ENSGT00940000160302; -.
DR OrthoDB; 5406861at2759; -.
DR Proteomes; UP000002277; Chromosome X.
DR Bgee; ENSPTRG00000021796; Expressed in fibroblast and 19 other cell types or tissues.
DR GO; GO:0005776; C:autophagosome; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0006914; P:autophagy; IEA:Ensembl.
DR GO; GO:0060244; P:negative regulation of cell proliferation involved in contact inhibition; IEA:Ensembl.
DR GO; GO:0001845; P:phagolysosome assembly; IBA:GO_Central.
DR GO; GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR CDD; cd00033; CCP; 3.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 3.
DR InterPro; IPR025232; DUF4174.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR043555; SRPX-like.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR46343; HYR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46343:SF1; SUSHI REPEAT-CONTAINING PROTEIN SRPX; 1.
DR Pfam; PF13778; DUF4174; 1.
DR Pfam; PF02494; HYR; 1.
DR Pfam; PF00084; Sushi; 3.
DR SMART; SM00032; CCP; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 3.
DR PROSITE; PS50825; HYR; 1.
DR PROSITE; PS50923; SUSHI; 3.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..464
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015095824"
FT DOMAIN 67..117
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 118..176
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 175..259
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 260..319
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 147..174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 290..317
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 464 AA; 51572 MW; 9CD5E57BC2848680 CRC64;
MGSPAHRPAL LLLLPPLLLL LLLRVPPSRS FPGSGDSPLE DDEVGYSHPR YKDTPWCSPI
KVKYGDVYCR APQGGYYKTA LGTRCDIRCQ KGYELHGSSL LICQSNKRWS DKVICKQKRC
PTLAMPANGG FKCVDGAYFN SRCEYYCSPG YTLKGERTVT CMDNKAWSGR PASCVDMEPP
RIKCPSVKER IAEPNKLTVR VSWETPEGRD TADGILTDVI LKGLPPGSNF PEGDHKIQYT
VYDRAENKGT CKFRVKVRVK RCGKLNAPEN GYMKCSSDGD NYGATCEFSC IGGYELQGSP
ARVCQSNLAW SGTEPTCAAM NVNVGVRTAA ALLDQFYEKR RLLIVSTPTA RNLLYRLQLG
MLQQAQCGLD LRHITVVELV GVFPTLIGRI GAKIMPPALA LQLRLLLRIP LYSFSMVLVD
KHGMDKERYV SLVMPVALFN LIDTFPLRKE EMVLQAEMSQ TCNT
//
