ID K7BEC9_PANTR Unreviewed; 593 AA.
AC K7BEC9; A0A2J8MQI0; H2R9X2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Kelch like family member 2 {ECO:0000313|Ensembl:ENSPTRP00000053274.3};
DE SubName: Full=Kelch-like 2, Mayven {ECO:0000313|EMBL:JAA18533.1};
GN Name=KLHL2 {ECO:0000313|EMBL:JAA18533.1,
GN ECO:0000313|Ensembl:ENSPTRP00000053274.3, ECO:0000313|VGNC:VGNC:2983};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA18533.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000053274.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA18533.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA00731.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA40003.1}, Skin {ECO:0000313|EMBL:JAA24250.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA18533.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000053274.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04005145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04005146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01010607; JAA00731.1; -; mRNA.
DR EMBL; GABF01003612; JAA18533.1; -; mRNA.
DR EMBL; GABD01008850; JAA24250.1; -; mRNA.
DR EMBL; GABE01004736; JAA40003.1; -; mRNA.
DR RefSeq; XP_001150117.3; XM_001150117.5.
DR PaxDb; 9598-ENSPTRP00000053274; -.
DR Ensembl; ENSPTRT00000030803.5; ENSPTRP00000053274.3; ENSPTRG00000016572.6.
DR GeneID; 461590; -.
DR KEGG; ptr:461590; -.
DR CTD; 11275; -.
DR VGNC; VGNC:2983; KLHL2.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000156434; -.
DR OrthoDB; 5472491at2759; -.
DR TreeFam; TF329218; -.
DR Proteomes; UP000002277; Chromosome 4.
DR Bgee; ENSPTRG00000016572; Expressed in Brodmann (1909) area 10 and 21 other cell types or tissues.
DR CDD; cd18512; BACK_KLHL2_Mayven; 1.
DR CDD; cd18338; BTB_POZ_KLHL2_Mayven; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR044072; KLHL2_BTB/POZ.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412:SF35; ACTIN-BINDING PROTEIN IPP; 1.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR PRINTS; PR00501; KELCHREPEAT.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 56..123
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 593 AA; 65975 MW; 397AE02E69E56A18 CRC64;
METPPLPPAC TKQGHQKPLD SKDDNTEKHC PVTVNPWHMK KAFKVMNELR SQNLLCDVTI
VAEDMEISAH RVVLAACSPY FHAMFTGEMS ESRAKRVRIK EVDGWTLRML IDYVYTAEIQ
VTEENVQVLL PAAGLLQLQD VKKTCCEFLE SQLHPVNCLG IRAFADMHAC TDLLNKANTY
AEQHFADVVL SEEFLNLGIE QVCSLISSDK LTISSEEKVF EAVIAWVNHD KDVRQEFMAR
LMEHVRLPLL PREYLVQRVE EEALVKNSSA CKDYLIEAMK YHLLPTEQRI LMKSVRTRLR
TPMNLPKLMV VVGGQAPKAI RSVECYDFKE ERWHQVAELP SRRCRAGMVY MAGLVFAVGG
FNGSLRVRTV DSYDPVKDQW TSVANMRDRR STLGAAVLNG LLYAVGGFDG STGLSSVEAY
NIKSNEWFHV APMNTRRSSV GVGVVGGLLY AVGGYDGASR QCLSTVECYN ATTNEWTYIA
EMSTRRSGAG VGVLNNLLYA VGGHDGPLVR KSVEVYDPTT NAWRQVADMN MCRRNAGVCA
VNGLLYVVGG DDGSCNLASV EYYNPTTDKW TVVSSCMSTG RSYAGVTVID KPL
//
