ID   K7BI39_PANTR            Unreviewed;       788 AA.
AC   K7BI39; H2QAM2;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Pyridoxal-dependent decarboxylase domain containing 1 {ECO:0000313|EMBL:JAA29926.1};
GN   Name=PDXDC1 {ECO:0000313|EMBL:JAA29926.1,
GN   ECO:0000313|Ensembl:ENSPTRP00000013301.4};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA29926.1};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000013301.4, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|EMBL:JAA29926.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA11281.1}, Skin
RC   {ECO:0000313|EMBL:JAA29926.1}, and Smooth vascular
RC   {ECO:0000313|EMBL:JAA19227.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT   mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000013301.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR   EMBL; AC193033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GABC01000057; JAA11281.1; -; mRNA.
DR   EMBL; GABF01002918; JAA19227.1; -; mRNA.
DR   EMBL; GABD01003174; JAA29926.1; -; mRNA.
DR   RefSeq; XP_016784957.1; XM_016929468.1.
DR   PaxDb; 9598-ENSPTRP00000013301; -.
DR   Ensembl; ENSPTRT00000014352.4; ENSPTRP00000013301.4; ENSPTRG00000007799.5.
DR   GeneID; 453941; -.
DR   CTD; 23042; -.
DR   eggNOG; KOG0630; Eukaryota.
DR   GeneTree; ENSGT00390000009628; -.
DR   OrthoDB; 3142408at2759; -.
DR   TreeFam; TF313101; -.
DR   Proteomes; UP000002277; Chromosome 16.
DR   Bgee; ENSPTRG00000007799; Expressed in testis and 21 other cell types or tissues.
DR   GO; GO:0016830; F:carbon-carbon lyase activity; IEA:InterPro.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.90.1150.170; -; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   PANTHER; PTHR42735; -; 1.
DR   PANTHER; PTHR42735:SF1; PYRIDOXAL-DEPENDENT DECARBOXYLASE DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   2: Evidence at transcript level;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT   REGION          684..788
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        741..766
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        769..788
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   788 AA;  86703 MW;  7DE7C28BCD2AECC6 CRC64;
     MDASLEKIAD PTLAEMGKNL KEAVKMLEDS QTRTEEENGK KLVSGDIPGP LQGSGQDMVS
     ILQLVQNLMH GDEDEEPQSP RIQNIGEQGH MALLGHSLGA YISTLDKEKL RKLTTRILSD
     TTLWLCRIFR YENGCAYFHE EEREGLAKIC RLAIHSRYED FVVDGFNVLY NKKPVIYLSA
     AARPGLGQYL CNQLGLPFPC LCRVPCNTMF GSQHQMDVAF LEKLIKDDIE RGRLPLLLVA
     NAGTAAVGHT DKIGRLKELC EQYGIWLHVE GVNLATLALG YVSSSVLAAA KCDSMTMTPG
     PWLGLPAVPA VTLYKHDDPA LTLVAGLTSN KPTDKLRALP LWLSLQYLGL DGFVERIKHA
     CQLSQRLQES LKKVNYIKIL VEDELSSPVV VFRFFQELPG SDPVFKAVPV PNMTPSAVGR
     ERHSCDALNR WLGEQLKQLV PAGGLTVMDL EAEGTCLRFS PLMTAAVLGT RGEDVDQLVA
     CIESKLPVLC CTLQLREEFK QEVEATAGLL YVDDPNWPGI GVVRYEHAND DKSSLKSDPE
     GEKIHAGLLK KLNELESDLT FKIGPEYKSM KSCLYVGMAS DDVDAAELVE TIVATAREIE
     ENSRLLENMT EVVRKGIQEA QVELQKASEE RLLEEGVLRQ IPVVGSVLNW FSPVQALQKG
     RTFNLTAGSL ESTEPIYVYK AQGAGVTLPP TPSGSRTKQR LPGQKPFKRS LRGSDALSET
     SSVSHIEDLE KVERLSGGLE QITLEASSTE GHPGAPSPQH TDQTEAFQKG VPHPEDDHPQ
     VEGPESLR
//