ID K7BUI0_PANTR Unreviewed; 337 AA.
AC K7BUI0; A0A2J8INM3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF {ECO:0000256|PIRNR:PIRNR037866};
GN Name=NHERF2 {ECO:0000313|Ensembl:ENSPTRP00000061416.1,
GN ECO:0000313|VGNC:VGNC:13773};
GN Synonyms=SLC9A3R2 {ECO:0000313|EMBL:JAA15620.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA15620.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000061416.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA15620.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA01506.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA38003.1}, Skin {ECO:0000313|EMBL:JAA24618.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA15620.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000061416.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Scaffold protein that connects plasma membrane proteins with
CC members of the ezrin/moesin/radixin family and thereby helps to link
CC them to the actin cytoskeleton and to regulate their surface
CC expression. {ECO:0000256|PIRNR:PIRNR037866}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Endomembrane system {ECO:0000256|ARBA:ARBA00004184,
CC ECO:0000256|PIRNR:PIRNR037866}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004184, ECO:0000256|PIRNR:PIRNR037866}.
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DR EMBL; AACZ04061589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01009832; JAA01506.1; -; mRNA.
DR EMBL; GABF01006525; JAA15620.1; -; mRNA.
DR EMBL; GABD01008482; JAA24618.1; -; mRNA.
DR EMBL; GABE01006736; JAA38003.1; -; mRNA.
DR RefSeq; XP_016784131.1; XM_016928642.1.
DR STRING; 9598.ENSPTRP00000061416; -.
DR Ensembl; ENSPTRT00000095812.1; ENSPTRP00000061416.1; ENSPTRG00000007627.5.
DR GeneID; 750047; -.
DR KEGG; ptr:750047; -.
DR CTD; 9351; -.
DR VGNC; VGNC:13773; NHERF2.
DR GeneTree; ENSGT00950000182849; -.
DR OMA; LWEPQPE; -.
DR OrthoDB; 2914289at2759; -.
DR Proteomes; UP000002277; Chromosome 16.
DR Bgee; ENSPTRG00000007627; Expressed in heart and 21 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0019902; F:phosphatase binding; IEA:Ensembl.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR CDD; cd00992; PDZ_signaling; 2.
DR Gene3D; 2.30.42.10; -; 2.
DR InterPro; IPR015098; EBP50_C.
DR InterPro; IPR017300; NHERF-1/NHERF-2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14191:SF4; NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2; 1.
DR PANTHER; PTHR14191; PDZ DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF09007; EBP50_C; 2.
DR Pfam; PF00595; PDZ; 2.
DR PIRSF; PIRSF037866; EBP50; 1.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR PROSITE; PS50106; PDZ; 2.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|PIRNR:PIRNR037866};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 11..91
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 151..231
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 109..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 337 AA; 37451 MW; 9DA5392E4E3AC67E CRC64;
MAAPEPLRPR LCRLVRGEQG YGFHLHGEKG RRGQFIRRVE PGSPAEAAAL RAGDRLVEVN
GVNVEGETHH QVVQRIKAVE GQTRLLVVDQ ETDEELRRRQ LTCTEEMAQQ GLPPAHDPWE
PKPDWAHTGS RSSEAGKKDV SGPLRELRPR LCHLRKGPQG YGFNLHSDKS RPGQYIRSVD
PGSPAARSGL RAQDRLIEVN GQNVEGLRHA EVVASIKARE DEARLLVVDP ETDEHFKRLR
VTPTEEHVEG PLPSPFTNGT SPAQLNGGSA CSSRSDLPGS DKDTEDGSAW KRDPFQESGL
HLSPTAAEAK EKARATRVNK RAPQMDWNRK REIFSNF
//
