ID K7C8F3_PANTR Unreviewed; 1758 AA.
AC K7C8F3; A0A2J8JK42;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=RB binding protein 6, ubiquitin ligase {ECO:0000313|Ensembl:ENSPTRP00000068102.1};
DE SubName: Full=Retinoblastoma binding protein 6 {ECO:0000313|EMBL:JAA20510.1};
GN Name=RBBP6 {ECO:0000313|EMBL:JAA20510.1,
GN ECO:0000313|Ensembl:ENSPTRP00000068102.1, ECO:0000313|VGNC:VGNC:5907};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA20510.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000068102.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA20510.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA09885.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA43245.1}, Skin {ECO:0000313|EMBL:JAA30100.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA20510.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000068102.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04047863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01001453; JAA09885.1; -; mRNA.
DR EMBL; GABF01001635; JAA20510.1; -; mRNA.
DR EMBL; GABD01003000; JAA30100.1; -; mRNA.
DR EMBL; GABE01001494; JAA43245.1; -; mRNA.
DR RefSeq; XP_016785132.1; XM_016929643.1.
DR Ensembl; ENSPTRT00000105582.1; ENSPTRP00000068102.1; ENSPTRG00000007897.6.
DR GeneID; 744733; -.
DR CTD; 5930; -.
DR VGNC; VGNC:5907; RBBP6.
DR GeneTree; ENSGT00940000157561; -.
DR OMA; NPPWVAP; -.
DR OrthoDB; 150979at2759; -.
DR Proteomes; UP000002277; Chromosome 16.
DR Bgee; ENSPTRG00000007897; Expressed in thymus and 21 other cell types or tissues.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd16620; vRING-HC-C4C4_RBBP6; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR014891; DWNN_domain.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR025829; Zn_knuckle_CX2CX3GHX4C.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15439:SF29; CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR15439; RETINOBLASTOMA-BINDING PROTEIN 6; 1.
DR Pfam; PF08783; DWNN; 1.
DR Pfam; PF04564; U-box; 1.
DR Pfam; PF13696; zf-CCHC_2; 1.
DR SMART; SM01180; DWNN; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51282; DWNN; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00047}.
FT DOMAIN 4..76
FT /note="DWNN"
FT /evidence="ECO:0000259|PROSITE:PS51282"
FT DOMAIN 161..175
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 259..300
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 326..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1287..1631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1648..1758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..609
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..653
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..732
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..995
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1002..1036
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1200..1221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1222..1245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1301..1326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1414..1545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1563..1591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1613..1631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1649..1688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1695..1716
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1740..1758
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1758 AA; 197349 MW; 67E67D9D91A7998F CRC64;
MSCVHYKFSS KLNYDTVTFD GLHISLCDLK KQIMGREKLK AADCDLQITN AQTKEEYTDD
NALIPKNSSV IVRRIPIGGV KSTSKTYVIS RTEPAMATTK AIDDSSASIS LAQLTKTANL
AEANASEEDK IKAMMSQSGH EYDPINYMKK PLGPPPPSYT CFRCGKPGHY IKNCPTNGDK
NFESGPRIKK STGIPRSFMM EVKDPNMKGA MLTNTGKYAI PTIDAEAYAI GKKEKPPFLP
EEPSSSSEED DPIPDELLCL ICKDIMTDAV VIPCCGNSYC DECIRTALLE SDEHTCPTCH
QNDVSPDALI ANKFLRQAVN NFKNETGYTK RLRKQLPPPP PPIPPPRPLI QRNLQPLMRS
PISRQQDPLM IPVTSSSTHP APSISSLTSN QSSLAPPVSG NPSSAPAPVP DITATVSISV
HSEKSDGPFR DSDNKILPAA ALASEHSKGT SSIAITALME EKGYQVPVLG TPSLLGQSLL
HGQLIPTTGP VRINTARPGG GRPGWEHSNK LGYLVSPPQQ IRRGERSCYR SINRGRHHSE
RSQRTQGPSL PATPVFVPVP PPPLYPPPPH TLPLPPGVPP PQFSPQFPPG QPPPAGYSVP
PPGFPPAPAN LSTPWVSSGV QTAHSNTIPT TQAPPLSREE FYREQRRLKE ESKSPYSGSS
YSRSSYTYSK SRSGSTRSRS YSRSFSRSHS RSYSRSPPYP RRGRGKSRNY RSRSRSHGYH
RSRSRSPPYR RYHSRSRSPQ AFRGQSPNKR NIPQGETERE YFNRYREVPP PYDMKAYYGR
SVDFRDPFEK ERYREWERKY REWYEKYYKG YAAGAQPRPS ANRENFSPER FVPLNIRNSP
FTRGRREDYV GGQSHRSRNI GSNYPEKLSA RDGHNQKDNT KSKEKESENA PGDGKGNKHK
KHRKRRKGEE SEGFLNPELL ETSRKSREPT GVEENKTDSL FVLPSRDDAT PVRDEPMDAE
SITFKSVSEK DKRERDKPKA KGDKTKRKND GSAVSKKENI VKPAKGPQEK VDGERERSPR
SEPPIKKAKE ETPKTDNTKS SSSSQKDEKI TGTPRKAHSK SAKEHQETKP VKEEKVKKDY
SKDVKSEKLT TKEEKAKKPN EKNKPLDNKG EKRKRKTEEK GVDKDFESSS MKISKLEVTE
IVKPSPKRKM EPDTEKMDRT PEKDKISLSV PAKKIKLNRE TGKKIGSTEN ISNTKEPSEK
LESTSSKVKQ EKVKGKVRRK VTGTEGSSST LVDYTSTSST GGSPVRKSEE KTDTKRTVIK
TMEEYNNDNT APAEDVIIMI QVPQSKWDKD DFESEEEDVK STQPISSVGK PASVIKNVST
KPSNIVKYPE KESEPSEKIQ KFTKDVSHEI IQHEVKSSKN SASSEKGKTK DRDYSVLEKE
NPEKRKNSTQ PEKESNLDRL NEQGNFKSLS QSSKEARTSD KHDSTRASSN KDFTPNRDKK
TDYDTREYSS SKRRDEKNEL TRRKDSPPRN KDSASGQKNK PREERDLPKK GTGDSKKSNS
SPSRDRKPHD HKAPYDTKRP NEETKSVDKN PCKDREKHVL EARNNKESSG NKLLYILNPP
ETQVEKEQIT GQIDKNTVKP KPQLSHSSRL SSDLTRETDE AAFEPDYNES DSESNVSVKE
EESSGNISKD LKDKIVEKAK ESLDTAAVVQ VGISRNQSHS SPSVSPSRSH SPSGSQTRSH
SSSASSAESQ DSKKKKKKKE KKKHKKHKKH KKHKKHAGTE VELEKSQKHK HKKKKSKKNK
DKEKEKEKDD QKVKSVTV
//
