ID K7CJP1_PANTR Unreviewed; 659 AA.
AC K7CJP1; A0A2J8JZS2; H2QEA4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Centrosomal protein of 76 kDa {ECO:0000256|ARBA:ARBA00015706};
GN Name=CEP76 {ECO:0000313|EMBL:JAA42796.1,
GN ECO:0000313|Ensembl:ENSPTRP00000016812.4, ECO:0000313|VGNC:VGNC:5150};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA42796.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000016812.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA42796.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA02144.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA42796.1}, and Smooth vascular
RC {ECO:0000313|EMBL:JAA15367.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000016812.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Centrosomal protein involved in regulation of centriole
CC duplication. Required to limit centriole duplication to once per cell
CC cycle by preventing centriole reduplication.
CC {ECO:0000256|ARBA:ARBA00024729}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000256|ARBA:ARBA00004114}.
CC -!- SIMILARITY: Belongs to the CEP76 family.
CC {ECO:0000256|ARBA:ARBA00005400}.
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DR EMBL; AACZ04060026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01009194; JAA02144.1; -; mRNA.
DR EMBL; GABF01006778; JAA15367.1; -; mRNA.
DR EMBL; GABE01001943; JAA42796.1; -; mRNA.
DR RefSeq; XP_016788752.1; XM_016933263.1.
DR STRING; 9598.ENSPTRP00000016812; -.
DR PaxDb; 9598-ENSPTRP00000016812; -.
DR Ensembl; ENSPTRT00000018149.4; ENSPTRP00000016812.4; ENSPTRG00000009882.4.
DR GeneID; 455506; -.
DR KEGG; ptr:455506; -.
DR CTD; 79959; -.
DR VGNC; VGNC:5150; CEP76.
DR eggNOG; ENOG502QQEI; Eukaryota.
DR GeneTree; ENSGT00390000000781; -.
DR OrthoDB; 315381at2759; -.
DR TreeFam; TF329324; -.
DR Proteomes; UP000002277; Chromosome 18.
DR Bgee; ENSPTRG00000009882; Expressed in testis and 21 other cell types or tissues.
DR GO; GO:0005814; C:centriole; IBA:GO_Central.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0046599; P:regulation of centriole replication; IBA:GO_Central.
DR Gene3D; 3.10.620.30; -; 1.
DR InterPro; IPR028926; CEP76-C2.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR PANTHER; PTHR46436; CENTROSOMAL PROTEIN OF 76 KDA; 1.
DR PANTHER; PTHR46436:SF1; CENTROSOMAL PROTEIN OF 76 KDA; 1.
DR Pfam; PF15627; CEP76-C2; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 100..257
FT /note="CEP76 C2"
FT /evidence="ECO:0000259|Pfam:PF15627"
SQ SEQUENCE 659 AA; 74417 MW; 603128BB08BEE518 CRC64;
MSLPPEKASE LKQLIHQQLS KMDVHGRIRE ILAETIREEL APDQQHLSTE DLIKALRRRG
IIDDVMKELN FVTDSVEQEL PSSPKQPICF DRQSTLKKTN IDPTRRYLYL QVLGGKAFLE
HLQEPEPLPG QVCSTFTLCL HYRNQRFRSK PVACACEPDF HDGFLLEVHR ESLGDGTRMA
DSTTMLSISD PIHMVLIKTD IFGETTLVAS YFLEWRSVLG SENGVTSLTV ELMGVGTESK
VSVGILNIKL EMYPPLNQTL SQEVVNTQLA LERQKTAEKE RLFLVYAKQW WREYLQIRPS
HNSRLVKIFA QDENGINRPV CSYVKPLRAG RLLDTPRQAA RFVNVLGYER APVIGGGGKQ
EQWCTLLAFL CRNKGDCEDH ANLLCSLLLG YGLEAFVCVG TKAKGVPHAW VMTCGTDGTI
TFWESLTGHR YIHKPTNPDE PPVAEQPKPL YPYRTIGCVF NHQMFLGNCQ PSDAVETCVF
DLNDESKWKP MSEEAIKSVC APGATTSLPP FPPLCASTID ASVTSNEIEM QLRLLVSEHR
KDLGLTTVWE DQLSYLLSPA LASYEFERTT SISAGNEEFQ DAIRRAVPDG HTFKGFPIHF
VYRNARRAFA TCLRSPFCEE IICCRGDQVR LAVRVRVFTY PESACAVWIM FACKYRSVL
//
