ID K7CQ46_PANTR Unreviewed; 1342 AA.
AC K7CQ46; A0A2J8MJT8; H2QKH8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Zinc finger protein 335 {ECO:0000313|EMBL:JAA34548.1, ECO:0000313|Ensembl:ENSPTRP00000023326.4};
GN Name=ZNF335 {ECO:0000313|EMBL:JAA34548.1,
GN ECO:0000313|Ensembl:ENSPTRP00000023326.4, ECO:0000313|VGNC:VGNC:6302};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA34548.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000023326.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA34548.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA06653.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA34548.1}, Skin {ECO:0000313|EMBL:JAA25649.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA12963.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000023326.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04052839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01004685; JAA06653.1; -; mRNA.
DR EMBL; GABF01009182; JAA12963.1; -; mRNA.
DR EMBL; GABD01007451; JAA25649.1; -; mRNA.
DR EMBL; GABE01010191; JAA34548.1; -; mRNA.
DR RefSeq; XP_016793505.1; XM_016938016.1.
DR RefSeq; XP_016793506.1; XM_016938017.1.
DR STRING; 9598.ENSPTRP00000023326; -.
DR PaxDb; 9598-ENSPTRP00000023326; -.
DR Ensembl; ENSPTRT00000025274.4; ENSPTRP00000023326.4; ENSPTRG00000023353.5.
DR GeneID; 458293; -.
DR KEGG; ptr:458293; -.
DR CTD; 63925; -.
DR VGNC; VGNC:6302; ZNF335.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000158508; -.
DR OMA; HKRAHVG; -.
DR OrthoDB; 4239435at2759; -.
DR TreeFam; TF332472; -.
DR Proteomes; UP000002277; Chromosome 20.
DR Bgee; ENSPTRG00000023353; Expressed in cerebellar cortex and 21 other cell types or tissues.
DR GO; GO:0035097; C:histone methyltransferase complex; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990226; F:histone methyltransferase binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0048854; P:brain morphogenesis; IEA:Ensembl.
DR GO; GO:0021895; P:cerebral cortex neuron differentiation; IEA:Ensembl.
DR GO; GO:0040029; P:epigenetic regulation of gene expression; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:Ensembl.
DR GO; GO:0050671; P:positive regulation of lymphocyte proliferation; IEA:Ensembl.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 7.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24403; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24403:SF36; ZINC FINGER PROTEIN 335; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR Pfam; PF13909; zf-H2C2_5; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 245..268
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 465..492
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 495..522
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 523..550
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 562..589
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 590..612
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 621..648
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 649..677
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 678..706
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1019..1046
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1047..1074
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1075..1102
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1103..1131
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..325
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..754
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1342 AA; 144925 MW; 10F8468C8CDCE2C3 CRC64;
MEENEVESSS DAAPGPGRPE EPSESGLGVG TSEAVSADSS DAAAAPGQAE ADDSGVGQSS
DRGSRSQEEV SESSSSADPL PNGYLPDSSS VSHGPVAGVT GGPPALVHSS ALPDPNMLVS
DCTASSSDLG SAIDKIIEST IGPDLIQNCI TVTSAEDGGA ETTRYLILQG PDDGAPMTSP
MSSSTLAHSL AAIEALADGP TSTSTCLEAQ GGPSSPVQLP PASGAEEPDL QSLEAMMEVV
VVQQFKCKMC QYRSSTKATL LRHMRERHFR PVAAAAAAAG KKGRLRKWST STKTQEEEGP
EEEDDDDIVD AGAIDDLEED SDYNPAEDEP RGRQLRLQRP TPSTPRPRRR PGRPRKLPRL
EISDLPDGVE GEPLVSSQSG QSPPEPQDPE APSSSGPGHL VALGKVSRTP VEAGVSQSDA
ENAAPSCPDE HDTLPRRRGR PSRRFLGKKY RKYYYKSPKP LLRPFLCRIC GSRFLSHEDL
RFHVNSHEAG DPQLFKCLQC SYRSRRWSSL KEHMFNHVGS KPYKCDECSY TSVYRKDVIR
HAAVHSRDRK KRPDPTPKLS SFPCPVCGRV YPMQKRLTQH MKTHSTEKPH MCDKCGKSFK
KRYTFKMHLL THIQAVANRR FKCEFCEFVC EDKKALLNHQ LSHVSDKPFK CSFCPYRTFR
EDFLLSHVAV KHTGAKPFAC EYCHFSTRHK KNLRLHVRCR HASSFEEWGR RHPEEPPSRR
RPFFSLQQIE ELKQQHSAAP GPPPSSPGPP EIPPEATTFQ SSEAPSLLCP DTLGGATIIY
QQGAEESTAM ATQTALDLLL NMSAQRELGG TALQVAVVKS EDVEAGLASP GGQPSPEGAT
PQVVTLHVAE PGGGAVAESQ LGPPDLPQIT LAPGPFGGTG YSVITAPPME EGTSAPGTPY
SEEPAGEAAQ AVVVSDTLKE AGTHYIMATD GTQLHHIELT ADGSISFPSP DALASGAKWP
LLQCGGLPRD GPEPPSPAKT HCIGDSQSSA SSPPATSKAL GLAVPPSPPS AATAASKKFS
CKICAEAFPG RAEMESHKRA HAGPGAFKCP DCPFSARQWP EVRAHMAQHS SLRPHQCSQC
SFASKNKKDL RRHMLTHTKE KPFACHLCGQ RFNRNGHLKF HIQRLHSPDG RKSGTPTARA
PTQTPTQTII LNSDDETLAT LHTALQSSHG VLGPERLQQA LSQEHIIVAQ EQTVTNQEEA
AYIQEITTAD GQTVQHLVTS DNQVQYIISQ DGVQHLLPQE YVVVPEGHHI QVQEGQITHI
QYEQGAPFLQ ESQIQYVPVS PGQQLVTQAQ LEAAAHSAVT AVADAAMAQA QGLFGTEETV
PEHIQQLQHQ GIEYDVITLA DD
//
