ID K7CWF9_PANTR Unreviewed; 324 AA.
AC K7CWF9; A0A2J8Q9I9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Natriuretic peptide receptor 3 {ECO:0000313|Ensembl:ENSPTRP00000090060.1};
DE SubName: Full=Natriuretic peptide receptor C/guanylate cyclase C (Atrionatriuretic peptide receptor C) {ECO:0000313|EMBL:JAA23857.1};
GN Name=NPR3 {ECO:0000313|EMBL:JAA23857.1,
GN ECO:0000313|Ensembl:ENSPTRP00000090060.1,
GN ECO:0000313|VGNC:VGNC:13558};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA23857.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000090060.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA23857.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skin {ECO:0000313|EMBL:JAA23857.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000090060.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AACZ04051508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABD01009243; JAA23857.1; -; mRNA.
DR RefSeq; XP_003310809.1; XM_003310761.4.
DR Ensembl; ENSPTRT00000107513.1; ENSPTRP00000090060.1; ENSPTRG00000016773.7.
DR GeneID; 471581; -.
DR KEGG; ptr:471581; -.
DR CTD; 4883; -.
DR VGNC; VGNC:13558; NPR3.
DR GeneTree; ENSGT00440000033872; -.
DR OrthoDB; 4523637at2759; -.
DR Proteomes; UP000002277; Chromosome 5.
DR Bgee; ENSPTRG00000016773; Expressed in adult mammalian kidney and 16 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd12841; TM_EphA1; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001170; ANPR/GUC.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR44755:SF1; ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3; 1.
DR PANTHER; PTHR44755; NATRIURETIC PEPTIDE RECEPTOR 3-RELATED; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR00255; NATPEPTIDER.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:JAA23857.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 266..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..206
FT /note="Receptor ligand binding region"
FT /evidence="ECO:0000259|Pfam:PF01094"
SQ SEQUENCE 324 AA; 36656 MW; C38DFF9C771B1A8B CRC64;
MEPSALGPWS LFPDLAPRDQ EGQVLAPRRC FRRECGQNEK VVIMCASSDT IRSIMLVAHR
HGMTSGDYAF FNIELFNSSS YGDGSWKRGD KHDFEAKQAY SSLQTVTLLR TVKPEFEKFS
MEVKSSVEKQ GLNMEDYVNM FVEGFHDAIL LYVLALHEVL RAGYSKKDGG KIIQQTWNRT
FEGIAGQVSI DANGDRYGDF SVIAMTDVEA GTQEVIGDYF GKEGRFEMRP NVKYPWGPLK
LRIDENRIVE HTNSSPCKSC GLEESAVTGI VVGALLGAGL LMAFYFFRKK YRITIERRTQ
QEESNLGKHR ELREDSIRSH FSVA
//
