ID K7CZ22_PANTR Unreviewed; 263 AA.
AC K7CZ22; A0A2J8JEJ4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=SplA/ryanodine receptor domain and SOCS box containing 2 {ECO:0000313|EMBL:JAA30235.1, ECO:0000313|Ensembl:ENSPTRP00000084231.1};
GN Name=SPSB2 {ECO:0000313|EMBL:JAA30235.1,
GN ECO:0000313|Ensembl:ENSPTRP00000084231.1,
GN ECO:0000313|VGNC:VGNC:57790};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA30235.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000084231.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA30235.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA07571.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA33568.1}, Skin {ECO:0000313|EMBL:JAA30235.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA11450.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000084231.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the SPSB family.
CC {ECO:0000256|ARBA:ARBA00010910}.
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DR EMBL; AC195634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01003767; JAA07571.1; -; mRNA.
DR EMBL; GABF01010695; JAA11450.1; -; mRNA.
DR EMBL; GABD01002865; JAA30235.1; -; mRNA.
DR EMBL; GABE01011171; JAA33568.1; -; mRNA.
DR RefSeq; XP_009422993.2; XM_009424718.2.
DR STRING; 9598.ENSPTRP00000084231; -.
DR Ensembl; ENSPTRT00000008500.5; ENSPTRP00000084231.1; ENSPTRG00000004596.5.
DR GeneID; 451800; -.
DR KEGG; ptr:451800; -.
DR CTD; 84727; -.
DR VGNC; VGNC:57790; SPSB2.
DR GeneTree; ENSGT01030000234629; -.
DR OMA; HAWEIGW; -.
DR OrthoDB; 65989at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000002277; Chromosome 12.
DR Bgee; ENSPTRG00000004596; Expressed in thymus and 21 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03719; SOCS_SSB2; 1.
DR CDD; cd12906; SPRY_SOCS1-2-4; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR037340; SSB2_SOCS.
DR PANTHER; PTHR12245; SPRY DOMAIN CONTAINING SOCS BOX PROTEIN; 1.
DR PANTHER; PTHR12245:SF2; SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Receptor {ECO:0000313|EMBL:JAA30235.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 26..221
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 211..263
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 263 AA; 28617 MW; 07324C670B598665 CRC64;
MGQTALAGGS SSTPTPQALY PDLSCPEGLE ELLSAPPPDL GAQRRHGWNP KDCSENIEVK
EGGLYFERRP VAQSTDGARG KRGYSRGLHA WEISWPLEQR GTHAVVGVAT ALAPLQTDHY
AALLGSNSES WGWDIGRGKL YHQSKGPGAP QYPAGTQGEQ LEVPERLLVV LDMEEGTLGY
AIGGTYLGPA FRGLKGRTLY PAVSAVWGQC QVRIRYLGER RAEPHSLLHL SRLCVRHTLG
DTRLGQVSAL PLPPAMKRYL LYQ
//
