ID K7D105_PANTR Unreviewed; 207 AA.
AC K7D105; A0A2J8K2N0; H2QGU0;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Protein lin-7 homolog {ECO:0000256|PIRNR:PIRNR038039};
GN Name=LIN7B {ECO:0000313|EMBL:JAA33129.1,
GN ECO:0000313|Ensembl:ENSPTRP00000019344.5, ECO:0000313|VGNC:VGNC:7789};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA33129.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000019344.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA33129.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA00649.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA33129.1}, and Skin {ECO:0000313|EMBL:JAA22402.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000019344.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in establishing and maintaining the asymmetric
CC distribution of channels and receptors at the plasma membrane of
CC polarized cells. {ECO:0000256|PIRNR:PIRNR038039}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004171}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004171}. Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|PIRNR:PIRNR038039};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202,
CC ECO:0000256|PIRNR:PIRNR038039}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00023767}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00023767}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Postsynaptic density membrane
CC {ECO:0000256|ARBA:ARBA00034098}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00034098}.
CC -!- SIMILARITY: Belongs to the lin-7 family.
CC {ECO:0000256|ARBA:ARBA00008546, ECO:0000256|PIRNR:PIRNR038039}.
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DR EMBL; AACZ04055852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01010689; JAA00649.1; -; mRNA.
DR EMBL; GABD01010698; JAA22402.1; -; mRNA.
DR EMBL; GABE01011610; JAA33129.1; -; mRNA.
DR RefSeq; XP_016791985.1; XM_016936496.1.
DR STRING; 9598.ENSPTRP00000019344; -.
DR PaxDb; 9598-ENSPTRP00000019344; -.
DR Ensembl; ENSPTRT00000020952.5; ENSPTRP00000019344.5; ENSPTRG00000011278.5.
DR GeneID; 747217; -.
DR KEGG; ptr:747217; -.
DR CTD; 64130; -.
DR VGNC; VGNC:7789; LIN7B.
DR eggNOG; KOG3550; Eukaryota.
DR GeneTree; ENSGT00940000153222; -.
DR OMA; PLGLERX; -.
DR OrthoDB; 4175920at2759; -.
DR TreeFam; TF316850; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000011278; Expressed in superior frontal gyrus and 21 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0097025; C:MPP7-DLG1-LIN7 complex; IBA:GO_Central.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; IEA:UniProtKB-UniRule.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0097016; F:L27 domain binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-UniRule.
DR GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR GO; GO:1903361; P:protein localization to basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR017365; LIN7.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14063; PROTEIN LIN-7 HOMOLOG; 1.
DR PANTHER; PTHR14063:SF7; PROTEIN LIN-7 HOMOLOG B; 1.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR PIRSF; PIRSF038039; Lin-7_homologue; 2.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 2: Evidence at transcript level;
KW Cell junction {ECO:0000256|PIRNR:PIRNR038039};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR038039};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483, ECO:0000256|PIRNR:PIRNR038039};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038039};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR038039};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR038039}.
FT DOMAIN 10..65
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 93..175
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 187..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 207 AA; 22896 MW; 63189D82706B9B00 CRC64;
MAALVEPLGL ERDVSRAVEL LERLQRSGEL PPQKLQALQR VLQSRFCSAI REVYEQLYDT
LDITGSAEIR AHATAKATVA AFTASEGHAH PRVVELPKTD EGLGFNIMGG KEQNSPIYIS
RVIPGGVADR HGGLKRGDQL LSVNGVSVEG EQHEKAVELL KAAQGSVKLV VRYTPRVLEE
MEARFEKMRS ARRRQQHQSY SSLESRG
//
