ID K7D2N1_PANTR Unreviewed; 759 AA.
AC K7D2N1; A0A2J8PNQ1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=MTSS I-BAR domain containing 1 {ECO:0000313|Ensembl:ENSPTRP00000083691.1};
DE SubName: Full=Metastasis suppressor 1 {ECO:0000313|EMBL:JAA39963.1};
GN Name=MTSS1 {ECO:0000313|EMBL:JAA39963.1,
GN ECO:0000313|Ensembl:ENSPTRP00000083691.1, ECO:0000313|VGNC:VGNC:838};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA39963.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000083691.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA39963.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA39963.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000083691.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04067511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABE01004776; JAA39963.1; -; mRNA.
DR RefSeq; XP_009454163.1; XM_009455888.2.
DR STRING; 9598.ENSPTRP00000083691; -.
DR Ensembl; ENSPTRT00000098958.1; ENSPTRP00000083691.1; ENSPTRG00000020570.6.
DR GeneID; 464381; -.
DR CTD; 9788; -.
DR VGNC; VGNC:838; MTSS1.
DR GeneTree; ENSGT00950000183156; -.
DR OrthoDB; 3875239at2759; -.
DR Proteomes; UP000002277; Chromosome 8.
DR Bgee; ENSPTRG00000020570; Expressed in liver and 21 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0003785; F:actin monomer binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0034334; P:adherens junction maintenance; IBA:GO_Central.
DR GO; GO:0007009; P:plasma membrane organization; IEA:InterPro.
DR GO; GO:0032233; P:positive regulation of actin filament bundle assembly; IBA:GO_Central.
DR CDD; cd07643; I-BAR_IMD_MIM; 1.
DR CDD; cd22060; WH2_MTSS1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR013606; I-BAR_dom.
DR InterPro; IPR030127; MTSS1/MTSS2.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR15708; ACTIN BUNDLING/MISSING IN METASTASIS-RELATED; 1.
DR PANTHER; PTHR15708:SF10; PROTEIN MTSS 1; 1.
DR Pfam; PF08397; IMD; 1.
DR Pfam; PF02205; WH2; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51338; IMD; 1.
DR PROSITE; PS51082; WH2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 1..254
FT /note="IMD"
FT /evidence="ECO:0000259|PROSITE:PS51338"
FT DOMAIN 731..748
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 259..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..638
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 82730 MW; F466F827FE4E46DC CRC64;
MEAVIEKECS ALGGLFQTII SDMKGSYPVW EDFINKAGKL QSQLRTTVVA AAAFLDAFQK
VADMATNTRG GTREIGSALT RMCMRHRSIE AKLRQFSSAL IDCLINPLQE QMEEWKKVAN
QLDKDHAKEY KKARQEIKKK SSDTLKLQKK AKKVDTLGRG DIQPQLDSAL QDVNDKYLLL
EETEKQAVRK ALIEERGRFC TFISMLRPVI EEEISMLGEI THLQTISEDL KSLTMDPHKL
PSSSEQVILD LKGSDYSWSY QTPPSSPSTT MSRKSSVCSS LNSVNSSDSR SSGSHSHSPS
SHYRYRSSNL AQQAPVRLSS VSSHDSGFIS QDAFQSKSPS PMPPEAPNQL SNGFSHYSLS
SESHVGPTGA GLFPHCLPAS RLLPRVTSVH LPDYAHYYTI GPGMFPSSQI PSWKDWAKPG
PYDQPLVNTL QRRKEKREPD PNGGGPTTVS GPPAAAEEAQ RPRSMTVSAA TRPGEEMEAC
EELALALSRG LQLDTQRSSR DSLQCSSGYS TQTTTPCCSE DTIPSQVSDY DYFSVSGDQE
ADQQEFDKSS TIPRNSDISQ SYRRMFQAKR PASTAGLPTT LGPAMVTPGV ATIRRTPSTK
PSVRRGTIGA GPIPIKTPVI PVKTPTVPDL PGVLPAPPDG PEERGEHSPE SPSVGEGPQG
VTSMPSSMWS GQASVNPPLP GPKPSIPEEH RQAIPESEAE DQEREPPSAT VSPGQIPESD
PAHLSPRDTP QGEDMLNAIR RGVKLKKTTT NDRSAPRFS
//
