ID K7DN48_PANTR Unreviewed; 512 AA.
AC K7DN48; A0A2J8L3F1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Discs large MAGUK scaffold protein 3 {ECO:0000313|Ensembl:ENSPTRP00000079405.1};
DE SubName: Full=Discs, large homolog 3 {ECO:0000313|EMBL:JAA36987.1};
GN Name=DLG3 {ECO:0000313|EMBL:JAA36987.1,
GN ECO:0000313|Ensembl:ENSPTRP00000079405.1,
GN ECO:0000313|VGNC:VGNC:12291};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA36987.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000079405.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA36987.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA36987.1}, and Smooth
RC vascular {ECO:0000313|EMBL:JAA18546.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000079405.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04024661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04024662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABF01003599; JAA18546.1; -; mRNA.
DR EMBL; GABE01007752; JAA36987.1; -; mRNA.
DR RefSeq; XP_016799191.1; XM_016943702.1.
DR Ensembl; ENSPTRT00000077361.1; ENSPTRP00000079405.1; ENSPTRG00000021999.4.
DR GeneID; 100609853; -.
DR CTD; 1741; -.
DR VGNC; VGNC:12291; DLG3.
DR GeneTree; ENSGT00940000159565; -.
DR OMA; ENMAQEN; -.
DR OrthoDB; 2879721at2759; -.
DR Proteomes; UP000002277; Chromosome X.
DR Bgee; ENSPTRG00000021999; Expressed in spleen and 19 other cell types or tissues.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF28; DISKS LARGE HOMOLOG 3; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 49..130
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 164..234
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 322..497
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 277..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 512 AA; 57937 MW; 9330A330FF9F8FE5 CRC64;
MERARKFSGS GLAMGLGSAS ASAWRRASQR WAWPLRSLRP GGDAREPRKI ILHKGSTGLG
FNIVGGEDGE GIFVSFILAG GPADLSGELR RGDRILSVNG VNLRNATHEQ AAAALKRAGQ
SVTIVAQYRP EEYSRFESKI HDLREQMMNS SMSSGSGSLR TSEKRSLYVR ALFDYDRTRD
SCLPSQGLSF SYGDILHVIN ASDDEWWQAR LVTPHGESEQ IGVIPSKKRV EKKERARLKT
VKFHARTGMI ESNRSIKTKR KKSFRLSRKF PFYKSKENMA QESSIQEQGV TSNTSDSESS
SKGQEDAILS YEPVTRQEIH YARPVIILGP MKDRVNDDLI SEFPHKFGSC VPHTTRPRRD
NEVDGQDYHF VVSREQMEKD IQDNKFIEAG QFNDNLYGTS IQSVRAVAER GKHCILDVSG
NAIKRLQQAQ LYPIAIFIKP KSIEALMEMN RRQTYEQANK IYDKAMKLEQ EFGEYFTAIV
QGDSLEEIYN KIKQIIEDQS GHYIWVPSPE KL
//
