ID K7DS63_PANTR Unreviewed; 551 AA.
AC K7DS63; A0A2J8KED8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=EBF transcription factor 3 {ECO:0000313|Ensembl:ENSPTRP00000084781.1};
DE SubName: Full=Early B-cell factor 3 {ECO:0000313|EMBL:JAA40967.1};
GN Name=EBF3 {ECO:0000313|EMBL:JAA40967.1,
GN ECO:0000313|Ensembl:ENSPTRP00000084781.1,
GN ECO:0000313|VGNC:VGNC:57516};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA40967.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000084781.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA40967.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA08577.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA40967.1}, and Smooth vascular
RC {ECO:0000313|EMBL:JAA18619.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000084781.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004489}.
CC -!- SIMILARITY: Belongs to the COE family. {ECO:0000256|ARBA:ARBA00010340,
CC ECO:0000256|RuleBase:RU004489}.
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DR EMBL; AACZ04039274; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04039275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01002761; JAA08577.1; -; mRNA.
DR EMBL; GABF01003526; JAA18619.1; -; mRNA.
DR EMBL; GABE01003772; JAA40967.1; -; mRNA.
DR RefSeq; XP_001142497.1; XM_001142497.4.
DR STRING; 9598.ENSPTRP00000088579; -.
DR Ensembl; ENSPTRT00000084220.1; ENSPTRP00000084781.1; ENSPTRG00000047103.1.
DR GeneID; 737690; -.
DR CTD; 253738; -.
DR VGNC; VGNC:57516; EBF3.
DR GeneTree; ENSGT00950000182859; -.
DR OMA; NEAATPC; -.
DR OrthoDB; 3641706at2759; -.
DR Proteomes; UP000002277; Chromosome 10.
DR Bgee; ENSPTRG00000047103; Expressed in lymph node and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd11606; COE_DBD; 1.
DR CDD; cd01175; IPT_COE; 1.
DR Gene3D; 1.10.287.4280; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.3180; Transcription factor COE1, DNA-binding domain; 1.
DR InterPro; IPR032200; COE_DBD.
DR InterPro; IPR038173; COE_DBD_sf.
DR InterPro; IPR032201; COE_HLH.
DR InterPro; IPR038006; COE_IPT.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR003523; Transcription_factor_COE.
DR InterPro; IPR018350; Transcription_factor_COE_CS.
DR PANTHER; PTHR10747; TRANSCRIPTION FACTOR COE FAMILY MEMBER; 1.
DR PANTHER; PTHR10747:SF4; TRANSCRIPTION FACTOR COE3; 1.
DR Pfam; PF16422; COE1_DBD; 1.
DR Pfam; PF16423; COE1_HLH; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR PROSITE; PS01345; COE; 1.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|RuleBase:RU004489};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004489};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004489};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004489};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004489};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004489};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004489};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004489}.
FT DOMAIN 253..337
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 60415 MW; 0813B855111FAB12 CRC64;
MFGIQENIPR GGTTMKEEPL GSGMNPVRSW MHTAGVVDAN TAAQSGVGLA RAHFEKQPPS
NLRKSNFFHF VLALYDRQGQ PVEIERTAFV DFVEKEKEPN NEKTNNGIHY KLQLLYSNGV
RTEQDLYVRL IDSMTKQAIV YEGQDKNPEM CRVLLTHEIM CSRCCDKKSC GNRNETPSDP
VIIDRFFLKF FLKCNQNCLK NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH
GRRARRLDPS EATPCIKAIS PSEGWTTGGA TVIIIGDNFF DGLQVVFGTM LVWSELITPH
AIRVQTPPRH IPGVVEVTLS YKSKQFCKGA PGRFVYTALN EPTIDYGFQR LQKVIPRHPG
DPERLPKEVL LKRAADLVEA LYGMPHNNQE IILKRAADIA EALYSVPRNH NQIPTLGNNP
AHTGMMGVNS FSSQLAVNVS ETSQANDQVG YSRNTSSVSP RGYVPSSTPQ QSNYNTVSTS
MNGYGSGAMA SLGVPGSPGF LNGSSANSPY GMKQKSAFAP VVRPQASPPP SCTSANGNGL
QAMSGLVVPP M
//
