ID K7DYT9_MONDO Unreviewed; 834 AA.
AC K7DYT9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000038690.2, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000038690.2, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000038690.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; K7DYT9; -.
DR Ensembl; ENSMODT00000041798.2; ENSMODP00000038690.2; ENSMODG00000045807.1.
DR eggNOG; KOG1075; Eukaryota.
DR GeneTree; ENSGT00940000153064; -.
DR HOGENOM; CLU_000680_1_3_1; -.
DR InParanoid; K7DYT9; -.
DR OMA; MEMKQIT; -.
DR TreeFam; TF329847; -.
DR Proteomes; UP000002280; Chromosome 1.
DR Bgee; ENSMODG00000045807; Expressed in blood and 5 other cell types or tissues.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd09076; L1-EN; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR25952; ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR25952:SF252; GENE, 17555-RELATED; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 497..772
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 834 AA; 96840 MW; 84C4B41C2AA6C9EF CRC64;
MPGSPQVTVI TLNVNGMNSP IKRKQIEEWI RIQNPTICCL QETHMRRVDT HKVRIKGWSK
TFWASSDRKK AGVAIMISDK AKAKIDLIKR DREGYYILLK GTLDNEEISL INIYAPNNIA
PKFLMEKLGE LKEEIDSKTI LVGDLNQPLS NLDKSNQKIN KKEVKEVNEI LEKLELIDIW
RKINRDKKEY TFFSAPHGTF TKIDHTLGHR NMAHKCRKAE IINAAFSDHK AIKITISNGT
WKTKSKTNWK LNNMILQNRL VREEIIETIN NFIEENDNGE TSFQTFWDAA KAVIRGKFIS
LSAYINKLGR AEINQLEMQI KKLESDQIKN PQQKTKLEIL KIKGEINKIE SDRTIDLINK
TRSWYFEKTN KIDKVLVNLI KKRKEEKQIN SIKDEKGDIT SEEEEIKAII RNYFAQLYGN
KYTNLSDMDE YIQKYKLPRL TEEEIEFLNN PISENEIHQA IKELPKKKSP GPDGFTSEFY
QTFREQLIPI LYKLFDIISK EGVLPNSFYD TNMVLIPKPG RSKTEKENYR PISLMNIDAK
ILNRILAKRL QQVIRRVIHH DQVGFIPGMQ GWFNIRKTIH IIDHINKQTN KNHMIISIDA
EKAFDKIQHP FLLKTLESIG IEGSFLKIIN SIYLKPSANI ICNGDKLDAF PIRSGVKQGC
PLSPLLFDIV LETLAVAIRE EKEIEGIKIG KEETKLSLFA DDMMVYLKNP RDSTKKLIEI
INNFSKVAGY KINPHKSSAF LYIFNTAQQQ KLEREIPFKI TLDKIKYLGI YLPRQTQELY
EHNYKTLATQ LKLDLSNWKN INCSWVGRAN IIKMTILPKL IYLFSAIPME KFTI
//
