ID K7E0P2_MONDO Unreviewed; 886 AA.
AC K7E0P2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000039343.2, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000039343.2, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000039343.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; K7E0P2; -.
DR Ensembl; ENSMODT00000042454.2; ENSMODP00000039343.2; ENSMODG00000045377.1.
DR eggNOG; ENOG502RZEF; Eukaryota.
DR GeneTree; ENSGT00940000153064; -.
DR HOGENOM; CLU_000680_2_2_1; -.
DR InParanoid; K7E0P2; -.
DR OMA; IMSHITT; -.
DR TreeFam; TF329847; -.
DR Proteomes; UP000002280; Chromosome 1.
DR Bgee; ENSMODG00000045377; Expressed in placenta and 2 other cell types or tissues.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd09076; L1-EN; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR25952; ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR25952:SF252; GENE, 17555-RELATED; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 497..772
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 886 AA; 103209 MW; 1EF26E55FD0ADFC5 CRC64;
MPGSPQMTII TLNVNGMNSP IKRRRIAEWI RIQNPTICCL QETHMRRVDT HKVRIKGWSK
TFWASTDRKK AGVVIMISDK ANAKIDLIKR DREGNYILLK GTIDNEEISL INMYAPNNIA
PKFLMEKLGE LKEEIDNKTI LVGDLNQPLS NLDKSNQKIN KKEVKEVNEI LEKLELIDIW
KKINRDKKEY TFFSAPHGTF TKIDHTLGHR NIAHKCRKAE IMNAAFSDHK AIKIMISNGT
WKTKSKTNWK LNNMILQNRL VKEEIIETIN NFIEENDNGE TSFQTFWDAA KAVIRGKFIS
LNAYINKQGR AEINQLEMQM KKLESDQIKN PQQKTKLEIL KIKGEINKIE SDRTIDLINE
TRSWYFEKTN KIDKVLVNLV KKRKEEKQIH SIKDEKGDST SNEEEIKAII RNYFAQLYGN
KYTNLGEMDE YIQKYKLPRL TEEEIEFLNN PISEIEIQQA IKELPKKKSP GPDGFTCEFY
QTFREQLIPI LYKLFDIISK EGVLPNSFYD TNMVLIPKPG RSKTEKENYR PISLMNIDAK
ILNRILAKRL QQVIRRIIHH DQVGFIPGMQ GWFNIRKTIH IIDHINKQTS KNHMIISIDA
EKAFDKIQHP FLLKTLESIG IEGSFLKIIN SIYLKPTANI ICNGDKLDAF PIRSGVKQGC
PLSPLLFDIV LETLAVAIRE DKGIEGIKIG KEETKLSLFA DDMMVYLKNP RDSTKKLIEI
INNFSKVAGY KINPHKSSAF LYISNTAQQQ ELEREIPFKI TLDKIKYLGI YLPRQTQELY
EHNYKTLATQ LKLDLNKWKN INCSWIGRAN IIKMTILPKL IYLFSAIPIE LPKYFFTDLE
KTITKFIWKN KRSRISREIM KKNHNKVHLE EQKIKDIQGN NEKKHI
//
