ID K7E285_MONDO Unreviewed; 681 AA.
AC K7E285;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000039886.2, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000039886.2, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000039886.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; K7E285; -.
DR Ensembl; ENSMODT00000042991.2; ENSMODP00000039886.2; ENSMODG00000028052.2.
DR GeneTree; ENSGT00940000153064; -.
DR HOGENOM; CLU_000680_2_2_1; -.
DR InParanoid; K7E285; -.
DR OMA; MFKESIE; -.
DR TreeFam; TF329847; -.
DR Proteomes; UP000002280; Chromosome 8.
DR Bgee; ENSMODG00000028052; Expressed in skeletal muscle tissue and 3 other cell types or tissues.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd09076; L1-EN; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR25952; ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR25952:SF252; GENE, 17555-RELATED; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 497..681
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 681 AA; 79061 MW; 694EF28ADA0390B8 CRC64;
MPGSPQMTII TLNVNGMNSP IKRRRIAEWI RIQNPTICCL QETHMRRVDT HKVRIKGWSK
TFWASTDRKK AGVVIMISDK ANAKIDLIKR DREGNYILLK GTIDNEEISL INMYAPNNIA
PKFLMEKLGE LKEEIDNKTI LVGDLNQPLS NLDKSNQKIN KKEVKEVNEI LEKLELIDIW
RKINRDKKEY TFFSAPHGTF TKIDHTLGHR NIAHKCRKAE IMNAAFSDHK AIKIMISNGT
WKTKSKTNWK LNNMILQNRL VKEEIIETIN NFIEENDNGE TSFQTFWDAA KAVIRGKFIS
LNAYINKQGR AEINQLEMQM KKLESDQIKN PQQKTKLEIL KIKGEINKIE SDRTIDLINE
TRSWYFEKTN KIDKVLVNLV KKRKEEKQIH SIKDEKGDST SNEEEIKAII RNYFAQLYGN
KYTNLGEMDE YIQKYKLPRL TEEEIEFLNN PISENEIQQA IKELPKKKSP GPDGFTCEFY
QTFREQLIPI LYKLFDIISK EGVLPNSFYD TNMVLIPKPG RSKTEKENYR PISLMNIDAK
ILNRILAKRL QQVIRRIIHH DQVGFIPGMQ GWFNIRKTIH IIDHINKQTS KNHMIISIDA
EKAFDKIQHP FLLKTLESIG IEGSFLKIMN SIYLKPTDNI ICNGDKLDAF PIRSGVKQGC
PLSPLLFDIV LETLAVAIRE D
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