ID K7E4E9_MONDO Unreviewed; 1744 AA.
AC K7E4E9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Mitogen-activated protein kinase kinase kinase 14 {ECO:0000313|Ensembl:ENSMODP00000040651.1};
GN Name=MAP3K14 {ECO:0000313|Ensembl:ENSMODP00000040651.1};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000040651.1, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000040651.1, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000040651.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 13616.ENSMODP00000040651; -.
DR Ensembl; ENSMODT00000043758.2; ENSMODP00000040651.1; ENSMODG00000011161.4.
DR eggNOG; KOG0027; Eukaryota.
DR eggNOG; KOG0198; Eukaryota.
DR GeneTree; ENSGT00940000156497; -.
DR HOGENOM; CLU_241531_0_0_1; -.
DR InParanoid; K7E4E9; -.
DR TreeFam; TF105120; -.
DR Proteomes; UP000002280; Chromosome 2.
DR Bgee; ENSMODG00000011161; Expressed in spermatid and 18 other cell types or tissues.
DR ExpressionAtlas; K7E4E9; baseline.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR CDD; cd13991; STKc_NIK; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR042787; M3K14_STKc.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR029297; SPATA32.
DR PANTHER; PTHR48016; MAP KINASE KINASE KINASE SSK2-RELATED-RELATED; 1.
DR PANTHER; PTHR48016:SF9; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF15310; VAD1-2; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT DOMAIN 381..634
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1504..1539
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 134..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1251..1304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1357..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1646..1744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..152
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..971
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1002..1040
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1255..1278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1290..1304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1720..1736
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 411
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1744 AA; 193206 MW; A5AF15BE37DAA224 CRC64;
MAVMEIMCQS APDSDVGHQK ELAKGKSQIP AKKSSSVCKL ETVEKNHVFC GQWEILNDVI
TKGTAKEGTE GGSASISIIA QAECENSQEF SPTFSERIFI AGSKQYSRSD SLDQIPNNVA
HSTEGKMTPA FWKAKRHRNK AGKKRKKKNS KVPGQRGGPL AKPLPKTPEQ ESCMIPVQED
ESSGLYFRNI PWFASPPKEM LLRPEKVGAG LQSALKTHPR AELHKLISPV QCLNHVWKLH
HPKDFFPQSD LLHSSPYKRL PHPFPFSPLL AQKPRPLGTF LLGNLTCVDN QHHLSDLKLE
TPCPRHGTSE KLSVEEYLVH ALKGSVSVGE PRNLTSLAKT WQGGGTGYWG PDPETEENEG
VLLNEKLKPV DYEYQEEVHW TKSQDCLGRG SFGEVYRMED KQTGFQCAVK KVHVQVFRAE
ELTACAGLTS PNFVPLYGAV KEGSWVNIFM ELMEGGSLGQ LIKQKGCLPE DRALYYLGQA
LEGLEYLHAR KILHGDVKAD NILLSGDGSR ALLCDFGHST GLQPDGLGKT FLTGNYVPGT
ETHMAPEVVM GKCCDSKVDI WSSCCMMLHM LNGCHPWTQY YSRPLCLKIA NEPPPVREIP
ASCTPFTTQA IKEGLEKEPV HRASATELRR KISLALQHVG GLKSPWRGPY KEPRRLPLNK
ENSLETLESL SLPSGSIPEA PGPGLAIEAM GSTTKLWPPL PPEPPEQNKL LPLSLSQEES
GTWEPLPLSS LSHISAKNSS SGERKPTSSD EELQQLEIEL FLDSLSQPYS LEEQEQMLSC
LSIDSLSLSD ASEKNLSKVS QSLRENFSSG IHSWNSQADG QSFSWDNLLG RSRHTDMPSY
FNGVNGFPCC SKKSVEVLET HRILKGKGSV GAQLHSFPLY DDEDKCPRPA SRAAFHYPTN
SSYKEEYKTK PFGGYNAFSQ QGSESDPLRD TEEEEEMEEE LEEEVEEEEE EELEEELEEE
EELEEELEEG GNKEESCTAP NKSMVETVAN WGTKAGEDFE DPEPQPEPVE DEIELLDDTL
ELEAEQDLES ESESDLESEL EPEAQLLPGS ESELEDEVPV PVSVFVQTSN LAFNLAPRNA
SKGPRVDVQI QTAVGPKGTL ELSISHEPRS SEPTPVKDGL HHTFRSVFVQ TSKHLFRMDK
VIQASDPTVH KLPLGIARHS SPVREWPFQK SLEKASKESL LSGNKLSKMF MEDVRGQTSH
PSLGIEGFPP QTPIQSLLPE NTSTEIQTIT SQNFSAKFSE PLDIRMLDSR PTSASLPPAL
VSSTMTSRNS SSTELALDSK APLSCKSSPG LRMESRSPMT QGSTTDLSLV AEQTVSPLPL
LKPPEAGEPQ KSINQEFALK PGYVSERVPM EGEVNHLQTP SLSPVPPGPW KEWSPAEGQE
IHSDTEMVQM DPGSMENEIG EGPTQLTPKL KKELLASWTA HQARARTGRG GAKPQSVDIP
LANRRRDISS LFAPVDIPAE YEHPLTSRQV AAFQDVFQLF KPGSQGKLDM RSMKGALRAV
GIQLSPQEVC EALRRADLDG DGAVDFDDFL GILTDNHRFA QCMGRMRNSR INDPHGLETL
FFEMMSKFVG QGALAPKSVA EVVSYYTDKQ RVLRMSSWWK GLNHKHNRSY RSRSHTGLSF
FCQATRLAGL NNRQLARSLH NLRDLNVQGP YSHVPNLPSR TRSTERRIRS RGPRLNNLAR
PCKPKPPQRE PPRRIPEPLG QRPQSEEGTA ELGPAPSPPT LVQSQLPSPP PATPQSHSLP
NVYQ
//
