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Database: UniProt
Entry: K7E6U3_ORNAN
LinkDB: K7E6U3_ORNAN
Original site: K7E6U3_ORNAN 
ID   K7E6U3_ORNAN            Unreviewed;       114 AA.
AC   K7E6U3;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   23-MAY-2018, entry version 26.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000029250, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000029250}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000029250};
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   STRING; 9258.ENSOANP00000029250; -.
DR   Ensembl; ENSOANT00000038495; ENSOANP00000029250; ENSOANG00000031204.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; K7E6U3; -.
DR   OrthoDB; EOG091G0RF6; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000031204; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   COILED       58     78       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   114 AA;  13037 MW;  A3549AD75DD1F133 CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIRKANIAIL DTGENPEVPF PRDMIDLEVS RPGEKGVGVS QGIV
//
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