ID K7EDT9_ORNAN Unreviewed; 2179 AA.
AC K7EDT9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|RuleBase:RU364134};
GN Name=MED13L {ECO:0000313|Ensembl:ENSOANP00000031696.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000031696.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000031696.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000031696.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000031696.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000031696.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC module termed the CDK8 module. Mediator containing the CDK8 module is
CC less active than Mediator lacking this module in supporting
CC transcriptional activation. Individual preparations of the Mediator
CC complex lacking one or more distinct subunits have been variously
CC termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR STRING; 9258.ENSOANP00000031696; -.
DR Ensembl; ENSOANT00000040943.2; ENSOANP00000031696.2; ENSOANG00000007288.4.
DR eggNOG; KOG3600; Eukaryota.
DR GeneTree; ENSGT00390000013680; -.
DR HOGENOM; CLU_1467746_0_0_1; -.
DR Proteomes; UP000002279; Chromosome 2.
DR Bgee; ENSOANG00000007288; Expressed in fibroblast and 7 other cell types or tissues.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF1; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13-LIKE; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 1402..1731
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1767..2168
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 357..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 992..1063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1206..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1520..1641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2015..2049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..528
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1040..1057
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1209..1231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1526..1541
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1556..1583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1604..1621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2179 AA; 235694 MW; E2A3472DE403725E CRC64;
MTAAANWVAN GASLEDCHSN LFSLAELTGI KWRRYDFGGH GECGPIISAP AQDDPILLSF
IRCLQANLLC VWRRDVKPDC RELWIFWWGD EPNLVDVIHQ ELHVVEEGLW ENGLSYECRT
LLFKAIHNLL ESEHLSCAFT FFLHGESNVC TSVEIAQHQP LYLLNQDHLH TAQASPAPFP
VLLSPYGLNG TLTGQAYKMA DPATRKLMED WQHFYPTVLK KKEEPKEDQD LGYDDDLPVA
VEVIVGGVRM VYPSALVLVS QNDVPVAAGG PGGPGQQGLG SGKDPGSCGM PLTPPTSPEQ
AVVGDGGGAQ SAFGHFPAQD GMITKHSPKR LGKTPPKLHN HMVHRVWKEC ILNRTQPKRS
QLATPNLEEE SSHNPASWDF ADPIQRVSCS CSRHKPFKQR CASGPARPPT IAQPGFAGGS
SASLPPPASS KHKTAERPEK GDKPQKRPTM PFHHRPSVAE ELCVDQDPAG QKLSLAAIDS
SPEVADGRKF EKQMALTSRN PGKPMNLNPM DSPHSPISPL PPTLSPQPRG PEAESLEAPS
VPGNPALYAN GLELQPFPGL DDRTVLVGQR LPVMAEVSET ALYCGIATPN HEASKKWHGY
RLPPSDDPEF RPPELRGEGY EDAKAEVNAD STALKRLLAQ PNKRFKIWEN KQAQVPLLNY
LDPLPVIQPA GEGLGELSDP YTFEDGDIKY SFTVNKRCKL GTEKDPLKKS KSEDGFGTKE
FPAPGHSTPV ADGKDAMSIF SPAPKTDARQ DNAASRAGSG SLTQVTDLAP SINDLDNIFD
NSDDDELGAV SPALRSSKLP AAGTEARTLG KEGRTAVPCP PTVTDLQRMF PTPPSLEQHP
AFSPVMNYKD GISSEAASAL GVLESPMVTT VPTQLTDFKM EVEEGMGSPK PEEMKDFSYV
HRATTFQPLV SSSMFAPLKM LPSQCLLPLK IPEACLFRPS WAIPPKIEQL PLPPTAPFIR
DGYNNVPSVG SLTDPDYLQI NTPVALNGAA PASNSGAGVL PSPATPRFSV PTPRTPRTPR
TPRGAGAASG QGSVKYDGPD QGSPASTPST SRPLSSVEPA TGRPVPEAHS LYVTLLLSDS
TLNIFKDRNF DSCCVCACNM NVKGADVGLY IPDSSHEDQY RCTCGFSAIM NRQLGYNSGL
FIEDELDIFG RTSDTGRAAE RRLTLCRTAP PPRDPPTSLL LLLQTQHAQP FSALACPDPA
PASCSPSRAA APSCPSSASS SSASSSASSA GGGPPPLHAS PGGAWTYDRV RADDNDSWVE
CFNALEQGRQ YVDNPTGGKV DEALVRAATV HSWPHSNVLD ISVLSSQDVV RMLLSLQPFL
QDAIQKKRTG RTWENIQHVQ GPLTWQQFHK MAGRGTYGSE ESPEPLPIPT LLVGYDKDFL
TISPFSLPFW ERLLMDPYGG HRDVAYIVVC PENEALLEGA KTFFRDLSAV YEMCRLGQHK
PICKVLQDGI MRVGETESQK LTDELVSEWF CQSWGSEESD NHSRLKLYAQ VCRHHLAPYL
ATLQLDSSLL VPPKYQAAAA PAAPASPHPG CAPPAPAPGI PPSAGSFHAG TNGGGGAANP
ASSAPPASSS STPAANPSAP ATSSGFGGGP AGGAAERNPG NGGEPESGPS SAQQPQQQEG
QESAPERDKI GIPTEPESAD SQAYPPAVVI YMVDPFTYTA EDGSASANFW LLSLMRCYTE
MLNNLPENMR SSFVLQIVPC QYMLQAMKGE QVFYIQHLKS MAFSVYCQCR RPLPTQIHIK
SLTGFGPAAS VEMTLKNPER PSPIQLYSPP FILAPIKDKQ TELGETFGEA SQKYNVLFVG
YCLSHDQRWL LASCTDLHGE LLETCIVNID LPNRSRRSKV SARKNGLQKL WEWCTGIVQM
TSLPWRVVIG RLGRLGHGEL KDWSTLLGEC SLQTISKQLK EACRMCGVSS ADSPSILSAC
LVAMEPQGSF VVMPDAVTMG SVFGRSTALN LQSSQLNTPQ DASCTHILVF PTSSTIQVAP
ANYPNEDGFS PNNDDMFDLP FPDDMDNDIG ILITGNLHSS PNSSPAPSPG SPGIGMGPHF
QHSRSQGERL LSREAPEELK QQPLALGYFV STAKAENLPQ WFWSACPQAQ NQCPLFLKAS
LHHHISVAQT DDLLPARNSQ RVPHPLDSKT TSDVLRFVLE QYNALSWLTC NPATQDRSSC
LPVHFVVLTQ LYNAIMNIL
//
