ID   K7EJU6_HUMAN            Unreviewed;       123 AA.
AC   K7EJU6;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Enhancer of zeste 1 polycomb repressive complex 2 subunit {ECO:0000313|Ensembl:ENSP00000465327.1};
GN   Name=EZH1 {ECO:0000313|Ensembl:ENSP00000465327.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000465327.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000465327.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000465327.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC100793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; K7EJU6; -.
DR   SMR; K7EJU6; -.
DR   MassIVE; K7EJU6; -.
DR   PeptideAtlas; K7EJU6; -.
DR   Ensembl; ENST00000586867.5; ENSP00000465327.1; ENSG00000108799.13.
DR   UCSC; uc060fmn.1; human.
DR   HGNC; HGNC:3526; EZH1.
DR   VEuPathDB; HostDB:ENSG00000108799; -.
DR   GeneTree; ENSGT00940000156604; -.
DR   HOGENOM; CLU_069235_2_0_1; -.
DR   ChiTaRS; EZH1; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000108799; Expressed in cerebellar hemisphere and 204 other cell types or tissues.
DR   ExpressionAtlas; K7EJU6; baseline and differential.
DR   GO; GO:0046976; F:histone H3K27 methyltransferase activity; IEA:InterPro.
DR   InterPro; IPR021654; EZH1/EZH2.
DR   Pfam; PF11616; EZH2_WD-Binding; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|MaxQB:K7EJU6,
KW   ECO:0007829|PeptideAtlas:K7EJU6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
SQ   SEQUENCE   123 AA;  14416 MW;  B47F782723885BFF CRC64;
     MEIPNPPTSK CITYWKRKVK SEYMRLRQLK RLQANMGAKA LYVANFAKVQ EKTQILNEEW
     KKLRVQPVQS MKPVSGHPFL KKCTIESIFP GFASQHMLMR SLNTVALVPI MYSWSPLQQN
     FMR
//