ID K7EKK3_HUMAN Unreviewed; 133 AA.
AC K7EKK3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
DE Flags: Fragment;
GN Name=USP32 {ECO:0000313|Ensembl:ENSP00000465659.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000465659.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000465659.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000465659.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR EMBL; AC003962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC025048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC037475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7EKK3; -.
DR SMR; K7EKK3; -.
DR MassIVE; K7EKK3; -.
DR MaxQB; K7EKK3; -.
DR PeptideAtlas; K7EKK3; -.
DR Antibodypedia; 31170; 95 antibodies from 24 providers.
DR Ensembl; ENST00000589335.5; ENSP00000465659.1; ENSG00000170832.13.
DR UCSC; uc060igy.1; human.
DR HGNC; HGNC:19143; USP32.
DR VEuPathDB; HostDB:ENSG00000170832; -.
DR GeneTree; ENSGT00940000155797; -.
DR HOGENOM; CLU_1911401_0_0_1; -.
DR ChiTaRS; USP32; human.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000170832; Expressed in left testis and 195 other cell types or tissues.
DR ExpressionAtlas; K7EKK3; baseline and differential.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR Gene3D; 3.30.2230.10; DUSP-like; 1.
DR InterPro; IPR035927; DUSP-like_sf.
DR InterPro; IPR006615; Pept_C19_DUSP.
DR SUPFAM; SSF143791; DUSP-like; 1.
DR PROSITE; PS51283; DUSP; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:K7EKK3,
KW ECO:0007829|MaxQB:K7EKK3};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 73..133
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT NON_TER 133
FT /evidence="ECO:0000313|Ensembl:ENSP00000465659.1"
SQ SEQUENCE 133 AA; 15316 MW; 32015719B7788A13 CRC64;
MGAKESRIGF LSYEEALRRV TDVELKRLKD AFKRTCGLSY YMGQHCFIRE VLGDGVPPKV
AEVCHIVLGL RPATPEEEGQ IIRGWLERES RYGLQAGHNW FIISMQWWQQ WKEYVKYDAN
PVVIEPSSVL NGG
//
