ID K7ELP4_HUMAN Unreviewed; 189 AA.
AC K7ELP4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Glial fibrillary acidic protein {ECO:0000313|Ensembl:ENSP00000466163.1};
DE Flags: Fragment;
GN Name=GFAP {ECO:0000313|Ensembl:ENSP00000466163.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466163.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000466163.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000466163.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: GFAP, a class-III intermediate filament, is a cell-specific
CC marker that, during the development of the central nervous system,
CC distinguishes astrocytes from other glial cells.
CC {ECO:0000256|ARBA:ARBA00002194}.
CC -!- SUBUNIT: Interacts with SYNM. {ECO:0000256|ARBA:ARBA00024375}.
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DR EMBL; AC015936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7ELP4; -.
DR SMR; K7ELP4; -.
DR MassIVE; K7ELP4; -.
DR MaxQB; K7ELP4; -.
DR PeptideAtlas; K7ELP4; -.
DR Antibodypedia; 3505; 3579 antibodies from 62 providers.
DR Ensembl; ENST00000588037.1; ENSP00000466163.1; ENSG00000131095.14.
DR UCSC; uc060gea.1; human.
DR HGNC; HGNC:4235; GFAP.
DR VEuPathDB; HostDB:ENSG00000131095; -.
DR GeneTree; ENSGT00940000159539; -.
DR ChiTaRS; GFAP; human.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000131095; Expressed in dorsal motor nucleus of vagus nerve and 142 other cell types or tissues.
DR ExpressionAtlas; K7ELP4; baseline and differential.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF9; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW Proteomics identification {ECO:0007829|MaxQB:K7ELP4,
KW ECO:0007829|PeptideAtlas:K7ELP4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 69..189
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 73..189
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 189
FT /evidence="ECO:0000313|Ensembl:ENSP00000466163.1"
SQ SEQUENCE 189 AA; 21280 MW; 46C6B09F71A70309 CRC64;
MERRRITSAA RRSYVSSGEM MVGGLAPGRR LGPGTRLSLA RMPPPLPTRV DFSLAGALNA
GFKETRASER AEMMELNDRF ASYIEKVRFL EQQNKALAAE LNQLRAKEPT KLADVYQAEL
RELRLRLDQL TANSARLEVE RDNLAQDLAT VRQKNVSPHS RLQDETNLRL EAENNLAAYR
QEADEATLA
//
