ID K7ELS9_HUMAN Unreviewed; 68 AA.
AC K7ELS9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
DE Flags: Fragment;
GN Name=PTPN2 {ECO:0000313|Ensembl:ENSP00000466206.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466206.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000466206.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0000313|Ensembl:ENSP00000466206.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AP001077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP002449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP005482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7ELS9; -.
DR SMR; K7ELS9; -.
DR MassIVE; K7ELS9; -.
DR MaxQB; K7ELS9; -.
DR PeptideAtlas; K7ELS9; -.
DR Antibodypedia; 6936; 335 antibodies from 34 providers.
DR Ensembl; ENST00000592059.5; ENSP00000466206.1; ENSG00000175354.20.
DR UCSC; uc060npd.1; human.
DR HGNC; HGNC:9650; PTPN2.
DR VEuPathDB; HostDB:ENSG00000175354; -.
DR GeneTree; ENSGT00940000154686; -.
DR HOGENOM; CLU_2800609_0_0_1; -.
DR ChiTaRS; PTPN2; human.
DR Proteomes; UP000005640; Chromosome 18.
DR Bgee; ENSG00000175354; Expressed in tendon of biceps brachii and 207 other cell types or tissues.
DR ExpressionAtlas; K7ELS9; baseline and differential.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR PANTHER; PTHR46047:SF1; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR46047; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:K7ELS9,
KW ECO:0007829|MaxQB:K7ELS9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 1..68
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT NON_TER 68
FT /evidence="ECO:0000313|Ensembl:ENSP00000466206.1"
SQ SEQUENCE 68 AA; 8080 MW; EE418D196A6B2D8E CRC64;
MVWQQKTKAV VMLNRIVEKE SVKCAQYWPT DDQEMLFKET GFSVKLLSED VKSYYTVHLL
QLENINVR
//
