ID K7ENE8_HUMAN Unreviewed; 77 AA.
AC K7ENE8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=FXYD domain-containing ion transport regulator {ECO:0000256|RuleBase:RU364131};
GN Name=FXYD7 {ECO:0000313|Ensembl:ENSP00000466915.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466915.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000466915.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000466915.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000256|ARBA:ARBA00005948,
CC ECO:0000256|RuleBase:RU364131}.
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DR EMBL; AC020907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF511265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7ENE8; -.
DR SMR; K7ENE8; -.
DR MassIVE; K7ENE8; -.
DR PeptideAtlas; K7ENE8; -.
DR Antibodypedia; 21550; 198 antibodies from 27 providers.
DR Ensembl; ENST00000586063.5; ENSP00000466915.1; ENSG00000221946.8.
DR UCSC; uc060wzq.1; human.
DR HGNC; HGNC:4034; FXYD7.
DR VEuPathDB; HostDB:ENSG00000221946; -.
DR GeneTree; ENSGT00940000153062; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000221946; Expressed in primary visual cortex and 93 other cell types or tissues.
DR ExpressionAtlas; K7ENE8; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0043269; P:regulation of monoatomic ion transport; IEA:InterPro.
DR CDD; cd20325; FXYD7; 1.
DR Gene3D; 1.20.5.780; Single helix bin; 1.
DR InterPro; IPR047284; FXYD7.
DR InterPro; IPR047297; FXYD_motif.
DR InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR PANTHER; PTHR14132:SF1; FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 7; 1.
DR PANTHER; PTHR14132; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA; 1.
DR Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR PROSITE; PS01310; FXYD; 1.
PE 1: Evidence at protein level;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU364131};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364131};
KW Proteomics identification {ECO:0007829|PeptideAtlas:K7ENE8,
KW ECO:0007829|ProteomicsDB:K7ENE8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364131};
KW Transmembrane helix {ECO:0000256|RuleBase:RU364131};
KW Transport {ECO:0000256|RuleBase:RU364131}.
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364131"
FT REGION 55..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 77 AA; 8151 MW; 531F92BE06C1CD31 CRC64;
MATPTQTPTK APEEPDPFYY DYNTVQTVGM TLATILFLLG ILIVISKKVK CRKADSSPTC
KSCKSELPSS APGGGGV
//
