ID K7EP76_HUMAN Unreviewed; 52 AA.
AC K7EP76;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Baculoviral IAP repeat-containing protein 5 {ECO:0000256|ARBA:ARBA00039922};
DE AltName: Full=Apoptosis inhibitor survivin {ECO:0000256|ARBA:ARBA00042407};
DE Flags: Fragment;
GN Name=BIRC5 {ECO:0000313|Ensembl:ENSP00000467259.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467259.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000467259.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0007829|PubMed:18691976}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [3] {ECO:0000313|Ensembl:ENSP00000467259.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Midbody
CC {ECO:0000256|ARBA:ARBA00004214}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the IAP family. {ECO:0000256|ARBA:ARBA00006672}.
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DR EMBL; AC087645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; K7EP76; -.
DR MaxQB; K7EP76; -.
DR PeptideAtlas; K7EP76; -.
DR Ensembl; ENST00000591800.1; ENSP00000467259.1; ENSG00000089685.15.
DR UCSC; uc060ktv.1; human.
DR HGNC; HGNC:593; BIRC5.
DR VEuPathDB; HostDB:ENSG00000089685; -.
DR GeneTree; ENSGT00510000047537; -.
DR HOGENOM; CLU_194783_0_0_1; -.
DR ChiTaRS; BIRC5; human.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000089685; Expressed in ventricular zone and 127 other cell types or tissues.
DR ExpressionAtlas; K7EP76; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:UniProt.
DR InterPro; IPR001370; BIR_rpt.
DR PANTHER; PTHR46771:SF3; BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR46771; DETERIN; 1.
DR Pfam; PF00653; BIR; 1.
DR SMART; SM00238; BIR; 1.
DR SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 1.
DR PROSITE; PS50143; BIR_REPEAT_2; 1.
PE 1: Evidence at protein level;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Proteomics identification {ECO:0007829|EPD:K7EP76,
KW ECO:0007829|MaxQB:K7EP76};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Thiol protease inhibitor {ECO:0000256|ARBA:ARBA00022704}.
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000467259.1"
SQ SEQUENCE 52 AA; 5980 MW; 5E1A73A7BBB1D51E CRC64;
XNWPFLEGCA CTPERMAEAG FIHCPTENEP DLAQCFFCFK ELEGWEPDDD PM
//
