ID K7EPN3_HUMAN Unreviewed; 100 AA.
AC K7EPN3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Receptor activity modifying protein 2 {ECO:0000313|Ensembl:ENSP00000467463.1};
GN Name=RAMP2 {ECO:0000313|Ensembl:ENSP00000467463.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467463.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000467463.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000467463.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAMP family.
CC {ECO:0000256|ARBA:ARBA00007087}.
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DR EMBL; AC100793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7EPN3; -.
DR SMR; K7EPN3; -.
DR MassIVE; K7EPN3; -.
DR PeptideAtlas; K7EPN3; -.
DR Antibodypedia; 29403; 312 antibodies from 32 providers.
DR Ensembl; ENST00000589683.5; ENSP00000467463.1; ENSG00000131477.11.
DR UCSC; uc060fna.1; human.
DR HGNC; HGNC:9844; RAMP2.
DR VEuPathDB; HostDB:ENSG00000131477; -.
DR GeneTree; ENSGT00940000160264; -.
DR HOGENOM; CLU_116349_2_0_1; -.
DR ChiTaRS; RAMP2; human.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000131477; Expressed in right lung and 138 other cell types or tissues.
DR ExpressionAtlas; K7EPN3; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.150.510; Receptor activity modifying family; 1.
DR InterPro; IPR006985; RAMP.
DR InterPro; IPR038126; RAMP_sf.
DR PANTHER; PTHR14076; RECEPTOR ACTIVITY MODIFYING PROTEIN RAMP; 1.
DR PANTHER; PTHR14076:SF9; RECEPTOR ACTIVITY-MODIFYING PROTEIN 2; 1.
DR Pfam; PF04901; RAMP; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:K7EPN3,
KW ECO:0007829|PeptideAtlas:K7EPN3};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 70..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 100 AA; 11505 MW; 6D822AFEBA0D904A CRC64;
MDPIEKDWCD WAMISRPYST LRDCLEHFAE LFDLGFPNPL AERIIFETHQ IHFANCSLVQ
PTFSDPPEDV LLAMIIAPIC LIPFLITLVV WRSKDSEAQA
//
