ID K7EQ44_HUMAN Unreviewed; 114 AA.
AC K7EQ44;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Transcription elongation factor 1 homolog {ECO:0000256|ARBA:ARBA00014973, ECO:0000256|RuleBase:RU364033};
GN Name=ELOF1 {ECO:0000313|Ensembl:ENSP00000467664.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467664.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000467664.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000467664.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcription elongation factor implicated in the maintenance
CC of proper chromatin structure in actively transcribed regions.
CC {ECO:0000256|ARBA:ARBA00003357, ECO:0000256|RuleBase:RU364033}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364033}.
CC -!- SIMILARITY: Belongs to the ELOF1 family.
CC {ECO:0000256|ARBA:ARBA00009730, ECO:0000256|RuleBase:RU364033}.
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DR EMBL; AC008481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC009001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7EQ44; -.
DR SMR; K7EQ44; -.
DR MassIVE; K7EQ44; -.
DR MaxQB; K7EQ44; -.
DR PeptideAtlas; K7EQ44; -.
DR Antibodypedia; 13205; 110 antibodies from 24 providers.
DR Ensembl; ENST00000586683.5; ENSP00000467664.1; ENSG00000130165.11.
DR UCSC; uc060tul.1; human.
DR HGNC; HGNC:28691; ELOF1.
DR VEuPathDB; HostDB:ENSG00000130165; -.
DR GeneTree; ENSGT00390000000053; -.
DR HOGENOM; CLU_105983_4_0_1; -.
DR ChiTaRS; ELOF1; human.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000130165; Expressed in left testis and 181 other cell types or tissues.
DR ExpressionAtlas; K7EQ44; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.20.25.190; -; 1.
DR InterPro; IPR007808; Elf1.
DR InterPro; IPR038567; T_Elf1_sf.
DR PANTHER; PTHR20934:SF0; TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG; 1.
DR PANTHER; PTHR20934; UNCHARACTERIZED; 1.
DR Pfam; PF05129; Elf1; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU364033};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364033};
KW Proteomics identification {ECO:0007829|EPD:K7EQ44,
KW ECO:0007829|MaxQB:K7EQ44};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364033};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364033};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU364033};
KW Zinc-finger {ECO:0000256|RuleBase:RU364033}.
FT REGION 88..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 114 AA; 12829 MW; E2232D9F834E0176 CRC64;
MGRRKSKRKP PPKKKMTGTL ETQFTCPFCN HEKSCDVKMD RARNTGVISC TVCLEEFQTP
ITSSAHPLLS VMSWVLRLPG HQKKERGPEA LTFGRWPGGP CDQPFKPPSV LFSQ
//
