ID K7EQA8_HUMAN Unreviewed; 343 AA.
AC K7EQA8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Histone-arginine methyltransferase CARM1 {ECO:0000256|ARBA:ARBA00021804};
DE EC=2.1.1.319 {ECO:0000256|ARBA:ARBA00011925};
DE AltName: Full=Coactivator-associated arginine methyltransferase 1 {ECO:0000256|ARBA:ARBA00033236};
DE AltName: Full=Protein arginine N-methyltransferase 4 {ECO:0000256|ARBA:ARBA00030670};
DE Flags: Fragment;
GN Name=CARM1 {ECO:0000313|Ensembl:ENSP00000467746.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000467746.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000467746.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0000313|Ensembl:ENSP00000467746.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) +
CC N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA-
CC COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319;
CC Evidence={ECO:0000256|ARBA:ARBA00001817};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AC007565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC011442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; K7EQA8; -.
DR MaxQB; K7EQA8; -.
DR PeptideAtlas; K7EQA8; -.
DR Ensembl; ENST00000586221.5; ENSP00000467746.1; ENSG00000142453.13.
DR UCSC; uc060tmy.1; human.
DR HGNC; HGNC:23393; CARM1.
DR VEuPathDB; HostDB:ENSG00000142453; -.
DR GeneTree; ENSGT00940000160377; -.
DR HOGENOM; CLU_786529_0_0_1; -.
DR ChiTaRS; CARM1; human.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000142453; Expressed in hindlimb stylopod muscle and 193 other cell types or tissues.
DR ExpressionAtlas; K7EQA8; baseline and differential.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0035242; F:protein-arginine omega-N asymmetric methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd13330; PH_CARM1; 1.
DR Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR020989; Histone-Arg_MeTrfase_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11006:SF51; HISTONE-ARGININE METHYLTRANSFERASE CARM1; 1.
DR PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR Pfam; PF11531; CARM1; 1.
DR Pfam; PF06325; PrmA; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
PE 1: Evidence at protein level;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01015};
KW Proteomics identification {ECO:0007829|EPD:K7EQA8,
KW ECO:0007829|MaxQB:K7EQA8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01015};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU01015}.
FT DOMAIN 2..98
FT /note="Histone-arginine methyltransferase CARM1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11531"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000467746.1"
SQ SEQUENCE 343 AA; 38419 MW; C5F82238D3D135CB CRC64;
XANGEIQRHA EQQALRLEVR AGPDSAGIAL YSHEDVCVFK CSVSRETECS RVGKQSFIIT
LGCNSVLIQF ATPNDFCSFY NILKTCRGHT LERSVFSERT EESSAVQYFQ FYGYLSQQQN
MMQDYVRTGT YQRAILQNHT DFKDKIVLDV GCGSGILSFF AAQAGARKIY AVEASTMAQH
AEVLVKSNNL TDRIVVIPGK VEEVSLPEQV DIIISEPMGY MLFNERMLES YLHAKKYLKP
SGNMFPTIGD VHLAPFTDEQ LYMEQFTKAN FWYQPSFHGV DLSALRGAAV DEYFRQPVVD
TFDIRILMAK SVKYTVNFLE AKEGDLHSAC LASPAATALC LPG
//
