ID K7ERI9_HUMAN Unreviewed; 77 AA.
AC K7ERI9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Apolipoprotein C-I {ECO:0000313|Ensembl:ENSP00000468276};
DE Flags: Fragment;
GN Name=APOC1 {ECO:0000313|Ensembl:ENSP00000468276};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000468276, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000468276, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000468276}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2012) to UniProtKB.
RN [3] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the apolipoprotein C1 family.
CC {ECO:0000256|ARBA:ARBA00009204}.
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DR EMBL; AC011481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7ERI9; -.
DR SMR; K7ERI9; -.
DR MassIVE; K7ERI9; -.
DR PeptideAtlas; K7ERI9; -.
DR Antibodypedia; 17780; 393 antibodies from 35 providers.
DR Ensembl; ENST00000592535; ENSP00000468276; ENSG00000130208.
DR UCSC; uc060zuj.1; human.
DR HGNC; HGNC:607; APOC1.
DR OpenTargets; ENSG00000130208; -.
DR VEuPathDB; HostDB:ENSG00000130208; -.
DR OMA; GTSTRNW; -.
DR ChiTaRS; APOC1; human.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000130208; Expressed in right lobe of liver and 181 other cell types or tissues.
DR ExpressionAtlas; K7ERI9; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:Ensembl.
DR Gene3D; 4.10.260.30; Apolipoprotein C-I; 1.
DR InterPro; IPR043081; ApoC-1_sf.
DR InterPro; IPR006781; ApoC-I.
DR PANTHER; PTHR16565; APOLIPOPROTEIN C-I; 1.
DR PANTHER; PTHR16565:SF2; APOLIPOPROTEIN C-I; 1.
DR Pfam; PF04691; ApoC-I; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:K7ERI9,
KW ECO:0007829|MaxQB:K7ERI9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..77
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003903303"
FT NON_TER 77
FT /evidence="ECO:0000313|Ensembl:ENSP00000468276"
SQ SEQUENCE 77 AA; 8647 MW; 3E6A2F1595706C74 CRC64;
MRLFLSLPVL VVVLSIVLEG PAPAQGTPDV SSALDKLKEF GNTLEDKARE LISRIKQSEL
SAKMREWFSE TFQKVKE
//
