ID   K7ETY9_PONAB            Unreviewed;       662 AA.
AC   K7ETY9;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Transmembrane anterior posterior transformation 1 {ECO:0000313|Ensembl:ENSPPYP00000024012.2};
GN   Name=TAPT1 {ECO:0000313|Ensembl:ENSPPYP00000024012.2};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000024012.2, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000024012.2, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000024012.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TAPT1 family.
CC       {ECO:0000256|ARBA:ARBA00008803}.
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DR   AlphaFoldDB; K7ETY9; -.
DR   Ensembl; ENSPPYT00000033276.2; ENSPPYP00000024012.2; ENSPPYG00000014621.3.
DR   GeneTree; ENSGT00390000010628; -.
DR   HOGENOM; CLU_003655_3_0_1; -.
DR   OMA; QPTHQKE; -.
DR   Proteomes; UP000001595; Chromosome 4.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   GO; GO:0045724; P:positive regulation of cilium assembly; IEA:Ensembl.
DR   InterPro; IPR008010; Tatp1.
DR   PANTHER; PTHR13317:SF4; TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG; 1.
DR   PANTHER; PTHR13317; UNCHARACTERIZED; 1.
DR   Pfam; PF05346; DUF747; 1.
PE   3: Inferred from homology;
KW   Chondrogenesis {ECO:0000256|ARBA:ARBA00023188};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        206..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        255..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        337..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        499..516
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        522..547
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          103..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          561..587
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          622..644
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        573..587
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        624..644
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   662 AA;  73333 MW;  E01072FB350CCA00 CRC64;
     MEPGAVPRPA EPATARETAA RHSEGRKKMA AAVAAAAASH ASLTPMARAG RRAADGGGGP
     GSGEGRGEAG KGPAGGGGRA RGWREAAGTV CCARNMAGVG DAAAPGEGGG GGVDGPQRDG
     RGEAEQPGGS GGQGPPPAPQ LTETLGFYES DRRRERRRGR TELSLLRFLS AELTRGYFLE
     HNEAKYTERR ERVYTCLRIP GELEKLMVFG IFLCLDAFLY VFTLLPLRVF LALFRLLTLP
     CYGLRDRRLL QPAQVCDILK GVILVICYFM MHYVDYSMMY HLIRGQSVIK LYIIYNMLEV
     ADRLFSSFGQ DILDALYWTA TEPKERKRAH IGVIPHFFMA VLYVFFHAIL IMVQATTLNV
     AFNSHNKSLL TIMMSNNFVE IKGSVFKKFE KNNLFQMSNS DIKERFTNYV LLLIVCLRNM
     EQFSWNPDHL WVLFPDVCMV IGSEIAVDIV KHAFITKFND ITADVYSEYR ASLAFDLVSS
     RQKNAYTDYS DSVARRMGFI PLPLAVLLIR VITSSIKVQG ILSYACVILF YFGLISLKVL
     NSIVLLGKSC QYVKEAKMEE KLSNPPPTCT PGKPSSKSQN KCKPSQGLSA EENLSASVTK
     QPIHQKENII PLLVTSNSDQ FLTTPDGDEK DITQDNSELK HRSSKKDLLE IDRFTICGNR
     ID
//