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Database: UniProt
Entry: K7F2W3_PELSI
LinkDB: K7F2W3_PELSI
Original site: K7F2W3_PELSI 
ID   K7F2W3_PELSI            Unreviewed;       434 AA.
AC   K7F2W3;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   08-NOV-2023, entry version 50.
DE   RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE            EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
GN   Name=PLCD3 {ECO:0000313|Ensembl:ENSPSIP00000002373.1};
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC   Trionychidae; Pelodiscus.
OX   NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000002373.1, ECO:0000313|Proteomes:UP000007267};
RN   [1] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG   Soft-shell Turtle Genome Consortium;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA   White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA   Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA   Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA   Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT   into the development and evolution of the turtle-specific body plan.";
RL   Nat. Genet. 45:701-706(2013).
RN   [3] {ECO:0000313|Ensembl:ENSPSIP00000002373.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC         bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC         diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC         ChEBI:CHEBI:203600; EC=3.1.4.11;
CC         Evidence={ECO:0000256|RuleBase:RU361133};
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DR   EMBL; AGCU01113531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01113532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01113533; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01113534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01113535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01113536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01113537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01113538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01113539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; K7F2W3; -.
DR   Ensembl; ENSPSIT00000002381.1; ENSPSIP00000002373.1; ENSPSIG00000002346.1.
DR   GeneTree; ENSGT00940000156993; -.
DR   HOGENOM; CLU_002738_3_2_1; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00275; C2_PLC_like; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR001192; PI-PLC_fam.
DR   InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR   InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR   PANTHER; PTHR10336:SF33; 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3; 1.
DR   PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF00388; PI-PLC-X; 1.
DR   PRINTS; PR00390; PHPHLIPASEC.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00148; PLCXc; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|RuleBase:RU361133};
KW   Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU361133};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        183..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          294..415
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          114..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   434 AA;  48076 MW;  D31B76901B453227 CRC64;
     CRCVELDCWE GPNGEPVIYH GHTLTSKILF RDAIESIRAY AFQHSAYPVI LSLENHCGPE
     QQATMARHMR AILGDMLLTQ TLDGLSPMEL PSPEQLKGKI LVKGKKLPDL ECDPKNSSVL
     LESNGEEEEE EEERMLRRAG RRGSRLPFPM SSFSERAART LIKESGTGRQ AGLPRPWGPR
     DTAGLGLGWA FAYAFALAFT LAHALAFAHT FAHAFALAHA FTLARTRTRI RTRTHIPHER
     REGPTCLGLA SELEPLPLDT CGPKSLAGFQ WTWVFSWEKQ GWKSSCSKAV ITHGAENPPP
     SCISEEPSQL SQKPLWGSLR TPEGAALWRH MRLMLGGAGG AGQLAQPVTL PVPRPPGFNP
     RWEETLSFQL QVPELALVRF VVEDYDTTSC NDFVGQFTLP FSCLREGYRH VHLLSRDGAS
     LAPATLFVHV QATK
//
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