ID K7F3R2_PELSI Unreviewed; 724 AA.
AC K7F3R2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=TATA-box binding protein associated factor 4b {ECO:0000313|Ensembl:ENSPSIP00000002672.1};
GN Name=TAF4B {ECO:0000313|Ensembl:ENSPSIP00000002672.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000002672.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000002672.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TAF4 family.
CC {ECO:0000256|ARBA:ARBA00006178}.
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DR EMBL; AGCU01113967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01113968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01113969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7F3R2; -.
DR STRING; 13735.ENSPSIP00000002672; -.
DR Ensembl; ENSPSIT00000002681.1; ENSPSIP00000002672.1; ENSPSIG00000002612.1.
DR eggNOG; KOG2341; Eukaryota.
DR GeneTree; ENSGT00390000011620; -.
DR HOGENOM; CLU_010576_2_0_1; -.
DR OMA; TQKPLDN; -.
DR TreeFam; TF316520; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0060261; P:positive regulation of transcription initiation by RNA polymerase II; IEA:Ensembl.
DR CDD; cd08045; TAF4; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 1.20.120.1110; TAFH/NHR1 domain; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR045144; TAF4.
DR InterPro; IPR007900; TAF4_C.
DR InterPro; IPR037249; TAFH/NHR1_dom_sf.
DR InterPro; IPR003894; TAFH_NHR1.
DR PANTHER; PTHR15138; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4; 1.
DR PANTHER; PTHR15138:SF17; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4B; 1.
DR Pfam; PF05236; TAF4; 1.
DR Pfam; PF07531; TAFH; 1.
DR SMART; SM00549; TAFH; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF158553; TAFH domain-like; 1.
DR PROSITE; PS51119; TAFH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 148..245
FT /note="TAFH"
FT /evidence="ECO:0000259|PROSITE:PS51119"
FT REGION 115..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 589..643
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 120..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 78078 MW; AE5F1956080276B4 CRC64;
LPTGTVLIRS NNGQLMLVSQ QAIARAQSQT QNNAGTRPSI PTSTPSVRIC TIQNTGTNLL
KKVVATPVKT VSQTTNSVAS TDRRPAVVQT AAATNSVMTV TTVKPPGTGT PVKLPVSGPP
APSVSQQATS VKGEGTTVAQ PNTSTETLEN VKKCKNFLAT LIKLASSGPQ APEMGQNVKN
LVQHLLEAKI EPEEFTKKLY VELKSSPQPY LVPFLKKSML ALRQLMPNAQ SFIQQCVQQQ
APIQAVVSTC ISTAPTSSTV VTTSALATTS LQPVKPVLAS AVVTGAQTVK PVPSTIRVTT
AAAPLQTVKP VSAPFQPANP VHMSAVATTS LQAVKPIFAS PVATTTTTPL QSLKSVIGTP
ISIKITQPKS TVAQSVHAQQ AVRVKQLVVQ QPSGSIVKQV ATLPQTATLT LQKPGEKRSP
LNALIQTNQV PAGSFLKQIT LPGNKILSLQ ASPVQKNKIK ENGTTSFRDE DDINDVTSMA
GVNLSEENAC ILATNSEVVG TLIRSCTDET FLSSEALQKK ILDIGRRHDI MEPNSDVVNL
ISHATQERLR GLLEKLTVIA QHRMTTYKDS NKYIMSSDTR AQLRFLEKLD HMEKQRKDEE
EREMLLRAAK SRSNKEDPEQ LRLKQKAKEM QQLELAQMQQ KEANLTALAA IGPRKKRPLD
SPNLGSGLEG LNGSAAASGS SGFSLTKQLF RPRITRVCLR DLIFCMEQER EMKHSLALYR
ALLK
//
