ID K7F5X4_PELSI Unreviewed; 393 AA.
AC K7F5X4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=26S proteasome non-ATPase regulatory subunit 11 {ECO:0000256|ARBA:ARBA00039723};
DE AltName: Full=26S proteasome regulatory subunit RPN6 {ECO:0000256|ARBA:ARBA00041252};
GN Name=PSMD11 {ECO:0000313|Ensembl:ENSPSIP00000003434.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000003434.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000003434.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the 26S proteasome, a multiprotein complex
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC This complex plays a key role in the maintenance of protein homeostasis
CC by removing misfolded or damaged proteins, which could impair cellular
CC functions, and by removing proteins whose functions are no longer
CC required. Therefore, the proteasome participates in numerous cellular
CC processes, including cell cycle progression, apoptosis, or DNA damage
CC repair. In the complex, PSMD11 is required for proteasome assembly.
CC Plays a key role in increased proteasome activity in embryonic stem
CC cells (ESCs): its high expression in ESCs promotes enhanced assembly of
CC the 26S proteasome, followed by higher proteasome activity.
CC {ECO:0000256|ARBA:ARBA00037179}.
CC -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC regulatory subunits (RP). The regulatory particle is made of a lid
CC composed of 9 subunits including PSMD11, a base containing 6 ATPases
CC and few additional components. {ECO:0000256|ARBA:ARBA00038658}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S9 family.
CC {ECO:0000256|ARBA:ARBA00007454}.
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DR EMBL; AGCU01011077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01011078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7F5X4; -.
DR STRING; 13735.ENSPSIP00000003434; -.
DR Ensembl; ENSPSIT00000003451.1; ENSPSIP00000003434.1; ENSPSIG00000003280.1.
DR eggNOG; KOG1463; Eukaryota.
DR GeneTree; ENSGT00530000063301; -.
DR HOGENOM; CLU_029573_2_1_1; -.
DR OMA; YESFEGF; -.
DR TreeFam; TF106230; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0022624; C:proteasome accessory complex; IEA:Ensembl.
DR GO; GO:0043248; P:proteasome assembly; IEA:Ensembl.
DR GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR Gene3D; 1.25.40.570; -; 1.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR040780; Rpn6_C_helix.
DR InterPro; IPR040773; Rpn6_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10678:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11; 1.
DR PANTHER; PTHR10678; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2; 1.
DR Pfam; PF01399; PCI; 1.
DR Pfam; PF18503; RPN6_C_helix; 1.
DR Pfam; PF18055; RPN6_N; 1.
DR SMART; SM00753; PAM; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 195..363
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
SQ SEQUENCE 393 AA; 44371 MW; 19D5ED56E2BA91C7 CRC64;
LVKRDVQEND EEAVQVKEQS ILELGSLLAK TGQAEELGGL LKYVRPFLNS ISKAKAARLV
RSLLDLFLDM EAATGQEVDL CLECIEWAKS EKRTFLRQAL EARLVSLYFD TKRYQEALQL
GSQLLRELKK MDDKALLVEV QLLESKTYHA LSNLPKARAA LTSARTTANA IYCPPKLQAA
LDMQSGIIHA AEEKDWKTAY SYFYEAFEGY DSIDSPKAIT ALKYMLLCKI MLNTPEDVQA
LVSGKLALRY AGRQTEALKC VAQASKNRSL ADFEKALTDY KVELRDDPII NTHLAKLYDN
LLEQNLIRVI EPFSRVQMEH ISSLIKLSKA DVERKLSQMI LDKKFHGILD QGEGVLIIFD
EPPVDKTYEA ALETIQNMSK VVDSLYNKAK KLT
//
