ID K7F6F1_PELSI Unreviewed; 1323 AA.
AC K7F6F1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIN2A {ECO:0000313|Ensembl:ENSPSIP00000003611.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000003611.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000003611.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104,
CC ECO:0000256|RuleBase:RU367118}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR EMBL; AGCU01201950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01201951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01201952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01201953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01201954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01201955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01201956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01201957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01201958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01201959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 13735.ENSPSIP00000003611; -.
DR Ensembl; ENSPSIT00000003630.1; ENSPSIP00000003611.1; ENSPSIG00000003434.1.
DR eggNOG; KOG1053; Eukaryota.
DR GeneTree; ENSGT00940000156222; -.
DR HOGENOM; CLU_002598_1_0_1; -.
DR OMA; MPDEFPS; -.
DR TreeFam; TF314731; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0017146; C:NMDA selective glutamate receptor complex; IEA:Ensembl.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:Ensembl.
DR GO; GO:0042734; C:presynaptic membrane; IEA:Ensembl.
DR GO; GO:0008021; C:synaptic vesicle; IEA:Ensembl.
DR GO; GO:0022849; F:glutamate-gated calcium ion channel activity; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004972; F:NMDA glutamate receptor activity; IEA:Ensembl.
DR GO; GO:0097553; P:calcium ion transmembrane import into cytosol; IEA:Ensembl.
DR GO; GO:0033058; P:directional locomotion; IEA:Ensembl.
DR GO; GO:0042417; P:dopamine metabolic process; IEA:Ensembl.
DR GO; GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
DR GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0042177; P:negative regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:0022008; P:neurogenesis; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR GO; GO:1903539; P:protein localization to postsynaptic membrane; IEA:Ensembl.
DR GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR GO; GO:0009611; P:response to wounding; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
DR GO; GO:0042428; P:serotonin metabolic process; IEA:Ensembl.
DR GO; GO:0030431; P:sleep; IEA:Ensembl.
DR GO; GO:0001964; P:startle response; IEA:Ensembl.
DR GO; GO:0008542; P:visual learning; IEA:Ensembl.
DR CDD; cd13718; PBP2_iGluR_NMDA_Nr2; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR018884; NMDAR2_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF407; GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF10565; NMDAR2_C; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 419..441
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 491..513
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 682..705
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 293..660
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 301..364
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 865..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 932..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1323 AA; 150945 MW; F468E3A53EC09A6A CRC64;
DLMSTFFQFG ASVQQEAIVM LKVMQDYDWH VFSLVTSTFP GYRDFISFIK TTVENSFVGW
DMQNVITLDT AIGDAKTQIQ LKKIHSSVIL LYCSKDEAVY ILDEARSLGL TGYDFFWIVP
SLVSGNTEIT PKEFPSGLIS ASYDEWDYSL ESRVRDGLGI ISTAASAMLE KYSFIPEAKT
SCYGQLEKNE RPSHTLYRFM MNVTWEGKDL SFTEDGYQVH PRLVVIVLNK DRKWEKVGKW
ENKTLSLRYS VWPRFSSFAD SDPDDNHLSI VTLEEAPFVI VEDMDPLTET CVKNTVPCRK
FVKINNSTNE GTNIKKCCKG FCIDILKKLS RTVKFTYDLY LVTNGKHGKK VNNVWNGMIG
EVVYQRAVMA VGSLTINEER SEVVDFSVPF VETGISVMVS RSNGTVSPSA FLEPFSASVW
VMMFVMLLIV SAMAVFIFEY FSPVGYNRNL AKGKAPHGPS FTIGKAVWLL WGLVFNNSVP
VQNPKGTTSK IMVSVWAFFA VIFLASYTAN LAAFMIQEEF VDQVTGLSDK KFQRPYDYSP
PFRFGTVPNG STERNIRNNY PDMHLYMTKY NQKGVEDALV SLKTGKLDAF IYDAAVLNYK
AGRDEGCKLV TIGSGYIFAT TGYGIALQKG SPWKRQIDLA LLQFVGDGEM EELETLWLTG
ICHNEKNEVM SSQLDIDNMA GVFYMLAAAM ALSLITFVWE HLFYWKLRFC FTGICTDKPG
LLFSISRGIF SCIHGVHIEE KKKSPDFTLT NSQTNMLKLL RTAKNMTNIN SSRINSPKRT
DDFIQRGSLI MDMVMDKGNL IFSENRSFQP QDNLFGDNMS ELQTFVSNRH KDNLNNYVFQ
GQHPLTLNES NPNTVEVAVT AEAKVNSRPR QLWKKSVESL RQESIRQSQG SQRENGSEEN
RQHSVKGQRY LPEEIVHSDV SETSSRATCH MEPEHNNKHH KTKDNVKKRS VGSKYPKDCS
EVELTYLKTK QSTPRDKIYT IDADKQPGLH VNPPQYIENI ILPETIEFPA VYQDHNDNYR
KAEHGKRTPL HNEDSLPNND QYKLYSKHYS LKDKNASLVE VNDKYRQNFT HCRSCLSNLP
SYTGHYSSRS PYKCDACLRM GNLYDIDEDQ ILQEAVNSEH PEEMYEHDWV QNNADQYQKK
NMLRINRQHS FDNLLDKCRE IDMGRPTRSI SLKEKERFLE GSSYANTFHA PPSKLFSNKS
SLTAQTLEDS KRSKSLYPDH SADNPFLHSC HDDQHLVFGR SPADLYKQSL ASKARNDNYS
RSSIRSTASY SSRDGRIHND MYLSEHVMPY VANKNSVYST PRVLNSCSNR RVYKKMPSIE
SDV
//