ID K7F6V7_PELSI Unreviewed; 936 AA.
AC K7F6V7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Dystrophin related protein 2 {ECO:0000313|Ensembl:ENSPSIP00000003767.1};
GN Name=DRP2 {ECO:0000313|Ensembl:ENSPSIP00000003767.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000003767.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000003767.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGCU01191910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01191911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01191912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006137502.1; XM_006137440.2.
DR AlphaFoldDB; K7F6V7; -.
DR Ensembl; ENSPSIT00000003787.1; ENSPSIP00000003767.1; ENSPSIG00000003570.1.
DR GeneID; 102451480; -.
DR KEGG; pss:102451480; -.
DR CTD; 1821; -.
DR GeneTree; ENSGT00940000153467; -.
DR HOGENOM; CLU_001187_0_0_1; -.
DR OrthoDB; 2880153at2759; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd16248; EFh_DRP-2; 1.
DR CDD; cd00176; SPEC; 1.
DR CDD; cd00201; WW; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 1.20.58.60; -; 2.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF16; DYSTROPHIN-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00435; Spectrin; 1.
DR Pfam; PF00397; WW; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00150; SPEC; 2.
DR SMART; SM00456; WW; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 2.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 337..370
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 590..646
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 22..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..908
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 106164 MW; 4C4149F8E4C4D32F CRC64;
MQPMVMQACP YTLPRCRERR TVEQPRLSST AQAQVKAAED GEGASRVTPQ APNSAYGPQL
PLEMNLCWNE IKKKSHSLRA RLEAFSDHSG KLQLPLQEII DWLGQKDEEL SAQLPLRGDV
LLVQQEKETH AAFMEEVKSR GPYIYSVLES AQAFLSQHPF EELEEPNSES KDASPRHRIQ
NVSRFVWKQA NVASELWEKL TARCVDQHRH IERTLEQLLE VKGAMEELGA TLDQAESVRG
AWEPIGDLFI DSLPEHIQAT KLFKEELSPM KDGVKLVNDL AHQLAISDVH LSMENSRALE
QINTRWKQLQ AAVNERLKQL QDAHRDFGPG SQHFLSTSVQ VPWERAISPN KVPYYINHQA
QTTCWDHPKM TELYQTLADL NNIKFSAYRT AMKLRRVQKA LRLDLVTLAT ALEIFNEHEL
QPMERVMDVV EVIHCLTALY ERLEEERGIL VNVPLCVDMS LNWLLNVFDS GRSGKMRALS
FKTGIACLCG TEVKEKFQYL FGQVANPGGL CDQRHLSILL HEAIQVPRQL GEVAAFGGSN
VEPSVRSCFR FSNGKPAIEG IQFLEWVNLE PQSMVWLAVL HRVTIAEQVK HQTKCSVCRQ
CPIKGFRYRS LKQFNVDICQ TCFLTGRASK GNKLHYPIME YYTPTTSSEN MRDFATTLKN
KFRSKQYFTK HPQRGYLPVQ SVLEADFTET PASSPMLPHA DTHSRIEHFA SRLAEMENQN
CSLFNDSLSP DDSLDEDQYL LRHSSPITDR ELGCSPKVGD SLNTEDKGEL ERILAHLEDE
NRILQGELRR LKWQHDEAVE SPAAAEGSPD GPPDPHNEEL LAEARILRQH KSRLETRMQI
LEDHNKQLES QLHRLRELLL QPPTDLDASG SAASSLASSP HPSEGSQPRE KEHPTPETEA
ADEVETRARD VSLCLEDIME KLRSAFPNAQ GVTSPI
//
