ID K7F811_PELSI Unreviewed; 410 AA.
AC K7F811;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=von Willebrand factor A domain-containing protein 1 {ECO:0000256|ARBA:ARBA00029542};
GN Name=VWA1 {ECO:0000313|Ensembl:ENSPSIP00000004171.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000004171.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000004171.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
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DR EMBL; AGCU01097639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01097640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01097641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01097642; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7F811; -.
DR STRING; 13735.ENSPSIP00000004171; -.
DR Ensembl; ENSPSIT00000004194.1; ENSPSIP00000004171.1; ENSPSIG00000003933.1.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00940000160734; -.
DR HOGENOM; CLU_042926_0_0_1; -.
DR OMA; PPVEDHL; -.
DR TreeFam; TF316402; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl.
DR GO; GO:0050436; F:microfibril binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0048266; P:behavioral response to pain; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
DR CDD; cd00063; FN3; 2.
DR CDD; cd01472; vWA_collagen; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF77; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 28..203
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 208..299
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 301..391
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 386..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 45111 MW; 0ECB07A324FF557D CRC64;
AWVTSPPSPP LCLLLSGLQP FIPDSEGDLL FLLDSSGSVS YYEFSRVKEF IRDLLRPFTF
SPSDVQTSII HISTTPTMEF PFDRYLSTGA VQQAIRDTQQ LMGDTNTGKA LSYAKEKFFT
DEAGARPDVP KVLVWVTDGF STDEISQPMQ LLKDMGVTVF IVSTGRGNYL QLSAAASQPP
EKHLHFVDVD DLPIITKELR DAIIDVIRAK RLRAVDITSS SFRLTWPRLL SNDIGYYVLE
YAPTDDPGRK LVKQVSGDHT SLLLSNLSPE TTYEVVLIPE SNVHYIPPQT TRVTTLEEEI
SPARVLISES RPHSFRVSWA PTPDSVGSYQ VLYGPLPGNS AQLLEVDGTH NSTVVENLAP
NTTYLVTVTA IYKSGKEKAL SAKACTQAGK RSQAPRSITS STGLVDARDP
//
