ID K7FA51_PELSI Unreviewed; 1262 AA.
AC K7FA51;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN Name=JAG2 {ECO:0000313|Ensembl:ENSPSIP00000004911.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000004911.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000004911.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AGCU01017203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006112802.1; XM_006112740.2.
DR AlphaFoldDB; K7FA51; -.
DR STRING; 13735.ENSPSIP00000004911; -.
DR Ensembl; ENSPSIT00000004938.1; ENSPSIP00000004911.1; ENSPSIG00000004542.1.
DR GeneID; 102452692; -.
DR KEGG; pss:102452692; -.
DR CTD; 3714; -.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000160944; -.
DR HOGENOM; CLU_004732_0_0_1; -.
DR OMA; KGTNCHI; -.
DR OrthoDB; 5475408at2759; -.
DR TreeFam; TF351835; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:Ensembl.
DR GO; GO:0005112; F:Notch binding; IEA:Ensembl.
DR GO; GO:0009912; P:auditory receptor cell fate commitment; IEA:Ensembl.
DR GO; GO:1990134; P:epithelial cell apoptotic process involved in palatal shelf morphogenesis; IEA:Ensembl.
DR GO; GO:0042492; P:gamma-delta T cell differentiation; IEA:Ensembl.
DR GO; GO:0016331; P:morphogenesis of embryonic epithelium; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:Ensembl.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0003016; P:respiratory system process; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0045061; P:thymic T cell selection; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 14.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR011651; Notch_ligand_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR45836:SF4; PROTEIN SLIT; 1.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 9.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 14.
DR SMART; SM00215; VWC_out; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 10.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 10.
DR PROSITE; PS50026; EGF_3; 14.
DR PROSITE; PS01187; EGF_CA; 4.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1106..1129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 214..258
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 325..363
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 365..401
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 403..439
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 441..477
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 479..514
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 516..552
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 554..590
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 619..656
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 658..694
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 696..732
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 734..770
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 773..809
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 811..847
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 849..885
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1137..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 216..225
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 229..241
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 249..258
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 353..362
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 391..400
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 429..438
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 467..476
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 483..493
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 504..513
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 542..551
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 580..589
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 646..655
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 684..693
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 722..731
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 760..769
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 799..808
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 837..846
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 875..884
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1262 AA; 139935 MW; 21EE3E70A0DD8F55 CRC64;
MLRAAAGPWL GSPVSDRLGA AGMLGSSRRH WAPLTAVLSL VLLLTLWVQV SQSTGYFELQ
FNSVKNVNGE LLNGECCDGM KSPQNLNCTR DECDTYVKVC LKEYQAKITS TGPCSYGFGS
TPVLGGNTFY LNNNKYSHQG RNQDVGRIVI PFQFAWPRSF TLVIEAWDWD NETKHDEELL
IERVAYAGMI NPEDRWKNLP FKGPVAQFEV QIRVKCDENY YSTRCNKFCG PRNDFVGHYT
CDQYGNKACM EGWMGEECKQ AVCKQGCNLL HGGCSIPGEC KCHYGWQGQF CDECVRYPGC
AHGSCKDPWQ CNCETNWGGL LCNKDLNYCG NHHPCVNGGT CMNTEPDEYH CACPDGYSGK
NCEIAEHACV SNPCANGGSC HEISSGFKCQ CPPGWSGPTC AVDINECESN PCARGGTCVD
RVNGFECICP QQWIGATCQL DANECEGKPC LNAYSCKNLI GGYYCDCIPG WKGVNCHINI
NDCKGQCENG GTCKDEVNGY YCLCPRGYLG KNCELEINEC ASNPCQNGGR CEDLVNGFHC
LCQQGFAGAF CEMDIDFCEP SPCQNGAKCY DLGGDYYCAC SDDYDGKNCS HLKDHCKNSS
CKVIDSCTIE VFTNTTQEGI RFISSNVCGP HGRCISQPGG NFTCACERGF TGTYCHENIN
DCLGKPCKNG GTCIDEVDSF RCFCLSGWEG ELCDTNFNDC SPNPCHNGGR CIDLVNDFYC
ECKNGWKGKT CHSREYQCDA NTCSNGGTCY DDGDTFRCSC PPEWKGSTCN IAKNSSCIPN
PCMNGGTCVG SGDSFSCICK EGWEGRTCTQ NTNDCNPHPC YNGGICVDGV NWFRCECAPG
FAGPDCRINI DECQSSPCAY GATCIDEING YRCTCPPGRI GPRCQEVIGF GKSCWLKGMS
FPHGSRWDQE CNNCHCLDGH IDCTKVWCGS KPCLLQKHQD HTNNWCPMGQ ECQEIMYIKC
FQPPCINWGE CSTSEPLPVN IKCPPSSGYL DNNCARITLI FNRDKVPQGT TIENICAEIR
YLPATRTVSR DRTLIVLCDL SYSTENAVEV AISFIPHQDE QDNSLIQNAA NTIVNAITKR
QNSTVMLAVT EVKVETIVVG HSSSDYLVPI LCVVFSIVWL TCIIICVWWT RKRRKERERS
RPPREESTNN QWAPLNPIRN PIDKPYSNKD IHYECKNFIS PQKRTCDAVE EYIEYEEEEE
EEEEREVMEM DKFLTNKLTI SLSAKASDTS DISPTKKSHH ISKMDNRSVK NVNASNFEGG
RG
//