ID K7FBX4_PELSI Unreviewed; 902 AA.
AC K7FBX4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Exosome component 10 {ECO:0000313|Ensembl:ENSPSIP00000005534.1};
GN Name=EXOSC10 {ECO:0000313|Ensembl:ENSPSIP00000005534.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000005534.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000005534.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR EMBL; AGCU01113087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01113088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01113089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01113090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006127108.1; XM_006127046.1.
DR AlphaFoldDB; K7FBX4; -.
DR STRING; 13735.ENSPSIP00000005534; -.
DR Ensembl; ENSPSIT00000005567.1; ENSPSIP00000005534.1; ENSPSIG00000005078.1.
DR GeneID; 102452155; -.
DR KEGG; pss:102452155; -.
DR CTD; 5394; -.
DR eggNOG; KOG2206; Eukaryota.
DR GeneTree; ENSGT00390000015408; -.
DR HOGENOM; CLU_010129_1_1_1; -.
DR OMA; NIMRPQM; -.
DR OrthoDB; 2880475at2759; -.
DR TreeFam; TF105991; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000791; C:euchromatin; IEA:Ensembl.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032040; C:small-subunit processome; IEA:Ensembl.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0071034; P:CUT catabolic process; IEA:Ensembl.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR GO; GO:0071044; P:histone mRNA catabolic process; IEA:Ensembl.
DR GO; GO:0032211; P:negative regulation of telomere maintenance via telomerase; IEA:Ensembl.
DR GO; GO:0071028; P:nuclear mRNA surveillance; IEA:Ensembl.
DR GO; GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IEA:Ensembl.
DR GO; GO:1905746; P:positive regulation of mRNA cis splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:1904872; P:regulation of telomerase RNA localization to Cajal body; IEA:Ensembl.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; IEA:Ensembl.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 515..595
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 20..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 744..774
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 598..620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..823
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 102912 MW; B0D77540839FE856 CRC64;
MAAAGGGGSR SAAVKTSQLM DAGSGGSTEE PPGGCPDTVL PGFRDADSFV KHALGTVVAA
TKASNGLPQP GDEYDFYRSF PGFRAYCETQ GDRLLHCMSK VMQYHGCRSH VKDHNKATEL
EDKFDLLVDS NDVILEKVGI LLDEAAGVNK NQQPILPAGM QVPKTIISSW NRKSGESHRT
KSEIFRLLHA KNITRPQLRF REKIDNSNTP FIPKLFVKPN ALKPLPEALA KSRRERKERP
EDLDVPAALA DFLHQQRIQQ TEQDMFAHPY QYELEHFVPP DAVLEKPQLQ MYRPVQDTPC
HFISTLDELV ELNEKLVSCK EFAVDLEHHS YRSFLGLTCL MQISTRMEDF IIDTLELRSD
MYILNEAFTD PAIVKVLHGA DSDVEWLQKD FGLYLVNMFD THQAARLLNL GRHSLDHLLK
LYCQVEADKR YQLADWRIRP LPEEMIQYAR DDTHYLLYIY DKVREALWER GNGQPTQLQV
VWQRSRDICL KKYIKPIFSE DSYLELYRRQ KKHLNTQQLT AFKLLFAWRD KMSRQEDEST
GYVLPNHMLL KIAEELPKEP QGIIACCNPI PPLVRQQINE MHLLIQQARE MPLLKSETET
GVKKKGSLPN PERLENHLFG PHDNSHVPLD DIQNFSNLEP APVLECGTLF PDNDGERDST
RILPNSACLV ATATISIFSE PDVDEGNEKN LTVAQQKARR IMESFENPFR MYLPSEQNPA
HISQSAKFDP SSKIYEISNR WKLMSQTQLQ IEAKEEAKKK AMQQRAAREQ VQKEYKATAE
NSVSVRQQAA QEQASKKRER ITSEPGSEMP KQEKKRPKAS QQPEEQETPK QFTPFDYSKS
NFKVFAGNST SKQSSQFDPA KQAHTGKKFS GANKLQHPAG NKSMSYLAGK TDRGSRHNWP
KR
//
