ID K7FC58_PELSI Unreviewed; 787 AA.
AC K7FC58;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Rho GTPase activating protein 44 {ECO:0000313|Ensembl:ENSPSIP00000005618.1};
GN Name=ARHGAP44 {ECO:0000313|Ensembl:ENSPSIP00000005618.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000005618.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000005618.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01141442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01141443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01141444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01141445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01141446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01141447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01141448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01141449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01141450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01141451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FC58; -.
DR STRING; 13735.ENSPSIP00000005618; -.
DR Ensembl; ENSPSIT00000005651.1; ENSPSIP00000005618.1; ENSPSIG00000005214.1.
DR eggNOG; KOG4270; Eukaryota.
DR GeneTree; ENSGT00940000157296; -.
DR HOGENOM; CLU_013806_0_0_1; -.
DR OMA; SDWIQAS; -.
DR TreeFam; TF316514; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0031256; C:leading edge membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF13; RHO GTPASE-ACTIVATING PROTEIN 44; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 1..226
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 233..427
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 438..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..532
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..715
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..781
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 787 AA; 85311 MW; AA01647F95D0E623 CRC64;
LPQVEKRLEL VKQVSHSTHK KLTACLQGQQ GVDADKRSVS GAGERRGCGP RRICGVVPGR
RPGEEAVAKK MLKLCGEAED KLAQELTSFE LEVERDVIEP LFVLAEVEIP NIQKQRKHLA
KLVLDMDSSR TRWQQSAKSS GLSSNLQPSG SKVDTLREEM EEAANRVEIC RDQLSADMYN
FVAKEIDYAN YFQTLIEVQA EYHRKSLALL QNVLPQIKAQ QAEAWIEKPS FGKPLEEHLA
ASGREIAFPI EACVTMLLEC GMQEEGLFRV APSASKLKKL KAALDCCVVD VQEYSADPHA
IAGALKSYLR ELPEPLMTFE LYDEWIQASN LQDQDKRLQA LWNACEKLPK ANHSNIRYLI
KFLAKLTEYQ DANKMTPSNV AIVLGPNLLW PQAEGVQSRL ETAVTAPGCP EPHPPHCSLL
PHPDIEFNVT GNYGSPMHVN HNANYSSMPS PDMDHADRKQ HDQARRPLSV ATDNMMLEFY
KKDGGLGSGE GMGVRVMDTS WVARRGTTVS RKASSTPPAV QPPAPPSDLS ATPQSPIPEQ
SLDISATPSP PPTSFGFPPA AERTSTLKTK ELSPVSGQKG SPGSGHAAPS GSIQPAASPT
QQLSTEQSPH ALRKVSKKLA PIPPKVPYGQ SGGMSDQSTG QPSPVSLSPT PPSTPSPYGL
NYPHGYSLAS GQLSPAAAPS LSSPSALTST LTKSRPTPKP RQRPTLPPPQ PPTASVAGAS
PQSMDHTLLD DMSPGESMST DLVRFDVPSI YIEGDAAPRR ELLEQSQRHS VAGKGDSEEE
ESESTAL
//
