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Database: UniProt
Entry: K7FD35_PELSI
LinkDB: K7FD35_PELSI
Original site: K7FD35_PELSI 
ID   K7FD35_PELSI            Unreviewed;       532 AA.
AC   K7FD35;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   31-JUL-2019, entry version 49.
DE   RecName: Full=Serine/threonine-protein kinase receptor {ECO:0000256|RuleBase:RU361271};
DE            EC=2.7.11.30 {ECO:0000256|RuleBase:RU361271};
GN   Name=BMPR1B {ECO:0000313|Ensembl:ENSPSIP00000005945};
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae;
OC   Pelodiscus.
OX   NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000005945, ECO:0000313|Proteomes:UP000007267};
RN   [1] {ECO:0000313|Ensembl:ENSPSIP00000005945}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17381049; DOI=10.1080/10425170600760091;
RA   Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.;
RT   "The complete mitochondrial genome of the Korean soft-shelled turtle
RT   Pelodiscus sinensis (Testudines, Trionychidae).";
RL   DNA Seq. 17:471-483(2006).
RN   [2] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG   Soft-shell Turtle Genome Consortium;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPSIP00000005945}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
CC         phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
CC         COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC         ChEBI:CHEBI:456216; EC=2.7.11.30;
CC         Evidence={ECO:0000256|SAAS:SAAS01128400};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-threonine + ATP = [receptor-
CC         protein]-O-phospho-L-threonine + ADP + H(+);
CC         Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-
CC         COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.30; Evidence={ECO:0000256|RuleBase:RU361271,
CC         ECO:0000256|SAAS:SAAS01128404};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU361271};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|RuleBase:RU361271};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361271};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU361271}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC       {ECO:0000256|RuleBase:RU361271, ECO:0000256|SAAS:SAAS00595019}.
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DR   EMBL; AGCU01012117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01012118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01012119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01012120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01012121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01012122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01012123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01012124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01012125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01012126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006112007.1; XM_006111945.2.
DR   RefSeq; XP_014431785.1; XM_014576299.1.
DR   RefSeq; XP_014431786.1; XM_014576300.1.
DR   RefSeq; XP_014431791.1; XM_014576305.1.
DR   RefSeq; XP_014431792.1; XM_014576306.1.
DR   RefSeq; XP_014431796.1; XM_014576310.1.
DR   RefSeq; XP_014431798.1; XM_014576312.1.
DR   RefSeq; XP_014431801.1; XM_014576315.1.
DR   RefSeq; XP_014431803.1; XM_014576317.1.
DR   Ensembl; ENSPSIT00000005980; ENSPSIP00000005945; ENSPSIG00000005496.
DR   GeneID; 102449724; -.
DR   KEGG; pss:102449724; -.
DR   CTD; 658; -.
DR   eggNOG; KOG2052; Eukaryota.
DR   eggNOG; ENOG410XQT0; LUCA.
DR   GeneTree; ENSGT00940000155919; -.
DR   KO; K13578; -.
DR   OrthoDB; 776697at2759; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0002063; P:chondrocyte development; ISS:AgBase.
DR   GO; GO:0060350; P:endochondral bone morphogenesis; ISS:AgBase.
DR   GO; GO:1902731; P:negative regulation of chondrocyte proliferation; ISS:AgBase.
DR   GO; GO:0061036; P:positive regulation of cartilage development; ISS:AgBase.
DR   GO; GO:0030166; P:proteoglycan biosynthetic process; ISS:AgBase.
DR   CDD; cd15116; 7tmA_CMKLR1; 1.
DR   InterPro; IPR000472; Activin_recp.
DR   InterPro; IPR002258; Chemokine-like_recpt_1.
DR   InterPro; IPR003605; GS_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255; PTHR23255; 1.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   PRINTS; PR00653; ACTIVIN2R.
DR   SMART; SM00467; GS; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138218};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007267};
KW   Kinase {ECO:0000256|RuleBase:RU361271, ECO:0000256|SAAS:SAAS00138139};
KW   Magnesium {ECO:0000256|RuleBase:RU361271};
KW   Manganese {ECO:0000256|RuleBase:RU361271};
KW   Membrane {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138203};
KW   Metal-binding {ECO:0000256|RuleBase:RU361271};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138212};
KW   Receptor {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138179};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW   Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138186}; Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138167};
KW   Transmembrane {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00138220};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361271,
KW   ECO:0000256|SAAS:SAAS00488859}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    532       Serine/threonine-protein kinase receptor.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003901525.
FT   TRANSMEM    157    178       Helical. {ECO:0000256|RuleBase:RU361271}.
FT   DOMAIN      204    233       GS. {ECO:0000259|PROSITE:PS51256}.
FT   DOMAIN      234    524       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
SQ   SEQUENCE   532 AA;  60303 MW;  327E025FF9576837 CRC64;
     MGWLEESNWQ LHISLIVLLS VHARANGLEH AYLRNSGKLN MENRKEDGES TASAPPQKPL
     QCHCNHHCPE DSVDSTCRTD GYCFTMVEED ESGGRTIASG CLGLEGSDFQ CRDTPIIHHK
     RTIACCTDKD FCNENLHPTL PPLKNRDFGE GNIHHKALLI SVTVCSILLV LVIIFCYFRH
     KRQETRPRYS IGLEQDETYI PPGESLKDLI EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI
     GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG
     SWTQLYLITD YHENGSLYDY LKSTTLDTKA MLKLAYSSVS GLCHLHTEIF STQGKPAIAH
     RDLKSKNILV KKNGTCCIAD LGLAVKFISD TNEVDIPPNT RVGTKRYMPP EVLDESLNRN
     HFQSYIMADM YSFGLILWEV ARRCVSGGIV EEYQLPYHDL VPTDPSYEDM REIVCIKKLR
     PSFPNRWSSD ECLRQMGKLM TECWAHNPAS RLTALRVKKT LAKMSESQDI KL
//
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