ID K7FDH5_PELSI Unreviewed; 320 AA.
AC K7FDH5;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Torsin {ECO:0000256|PIRNR:PIRNR038079};
GN Name=TOR1B {ECO:0000313|Ensembl:ENSPSIP00000006085.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000006085.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000006085.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|PIRNR:PIRNR038079}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC {ECO:0000256|ARBA:ARBA00006235, ECO:0000256|PIRNR:PIRNR038079}.
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DR EMBL; AGCU01121690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01121691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01121692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FDH5; -.
DR STRING; 13735.ENSPSIP00000006085; -.
DR Ensembl; ENSPSIT00000006121.1; ENSPSIP00000006085.1; ENSPSIG00000005624.1.
DR eggNOG; KOG2170; Eukaryota.
DR GeneTree; ENSGT00950000182888; -.
DR HOGENOM; CLU_053537_0_0_1; -.
DR OMA; CCDDRSI; -.
DR TreeFam; TF314941; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IEA:UniProtKB-UniRule.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IEA:Ensembl.
DR GO; GO:0071763; P:nuclear membrane organization; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049337; TOR1A_C.
DR InterPro; IPR010448; Torsin.
DR InterPro; IPR017378; Torsin_1/2.
DR PANTHER; PTHR10760; TORSIN; 1.
DR PANTHER; PTHR10760:SF14; TORSIN-1B; 1.
DR Pfam; PF21376; TOR1A_C; 1.
DR Pfam; PF06309; Torsin; 1.
DR PIRSF; PIRSF038079; Torsin_2A; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR038079-1};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR038079};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR038079-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..320
FT /note="Torsin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003901541"
FT DOMAIN 260..316
FT /note="Torsin-1A C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21376"
FT BINDING 90..97
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR038079-1"
SQ SEQUENCE 320 AA; 36121 MW; C0D9D4478DD8ACC3 CRC64;
RPGQGTMQLL LGLLSLLAPG SAALEPSSLG ALTAYSSYPS FYCGFVEVLP GEAERPNATA
LKEDLNNKLF GQHLAKDVIL KAVTGFSKHG WGGTGKNFVS QIIAKNIHKA GQKSKFVHLF
IATLHFPHAH QVSLYKDQLH KWIRGNVSAC ARSVFIFDEM DKLHPGLIDA IKPFLDYYEQ
IDGVSYRRAI FIFLSNAGGD LINKVTLDFW RSGKDREQIQ LKDLEPVLSV AVFNNKNSGL
WHSSLIDRNL IDYFVPFLPL EYKHVKMCIK AEIQSQGKEI DEAFVDKVAN EMTYFPKDEK
IYSDKGCKMV QDRLFFSWER
//
