ID K7FE73_PELSI Unreviewed; 544 AA.
AC K7FE73;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Myotubularin related protein 12 {ECO:0000313|Ensembl:ENSPSIP00000006333.1};
GN Name=MTMR12 {ECO:0000313|Ensembl:ENSPSIP00000006333.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000006333.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000006333.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; AGCU01042573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01042574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FE73; -.
DR STRING; 13735.ENSPSIP00000006333; -.
DR Ensembl; ENSPSIT00000006370.1; ENSPSIP00000006333.1; ENSPSIG00000005869.1.
DR eggNOG; KOG1089; Eukaryota.
DR GeneTree; ENSGT00940000160263; -.
DR HOGENOM; CLU_021912_1_1_1; -.
DR OMA; AFPKEQE; -.
DR TreeFam; TF315197; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR CDD; cd14594; PTP-MTMR12; 1.
DR InterPro; IPR022587; MTMR12-like_C.
DR InterPro; IPR030576; MTMR12_PTP.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF37; MYOTUBULARIN-RELATED PROTEIN 12; 1.
DR Pfam; PF12578; 3-PAP; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 2..439
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
SQ SEQUENCE 544 AA; 63695 MW; A8990C15FB896B7B CRC64;
MFDTIKDWRE ELERTKGNMK YKVVSANEAY KVSERLPLYF VVPMSLSEES ILQHQGRGIP
IWCWSCHNGA SLLKMSAFPK EQEDNTSQMH RLFLDGVYKT IHKPPYEVLK TDDLSNSLPS
LQDIHAAYTR FKQLFLIDNR TDFWDTDVKW FSLLESTNWL EIVRRCLKKA IEVVEYLEGQ
NTNVLLVEEY ASDLCCVISS LVQVMMDSHY RTKFGFQSLI QKEWVMGGHC FLDRCNHLRQ
NDKEEAPVFL LFLDCVWQLV QQYPPAFEFT ETYLTVLSDS LYIPIFSTFF FNSQHQKDTN
MSGESYNAQS SHFRFLTVWD WSVQFEPKAQ VLLNNPLYAE KQKLDRSQRK TTRFKHQRQL
SLPLTQTKSS PKRGFFREET DNFIKNILGK RISKLINSSD ELHNSTEFYD SWHCKPVDFH
GLLLPHIEGP GIKVWAQRYL RWIPEAQLVG GGIVATTTKV LDVMEEVQRL QKKMDEKHSQ
TVFQGREVLP MLRNSARLSS LFPFAMLQRN SLKPVLPTST WKDLEDEEDL AKRDDEFVDL
GEVI
//
