ID K7FEB0_PELSI Unreviewed; 781 AA.
AC K7FEB0;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Zinc finger FYVE-type containing 1 {ECO:0000313|Ensembl:ENSPSIP00000006370.1};
GN Name=ZFYVE1 {ECO:0000313|Ensembl:ENSPSIP00000006370.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000006370.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000006370.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01123397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01123398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01123399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01123400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01123401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01123402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006128648.1; XM_006128586.2.
DR AlphaFoldDB; K7FEB0; -.
DR STRING; 13735.ENSPSIP00000006370; -.
DR Ensembl; ENSPSIT00000006407.1; ENSPSIP00000006370.1; ENSPSIG00000005895.1.
DR GeneID; 102444072; -.
DR KEGG; pss:102444072; -.
DR CTD; 53349; -.
DR eggNOG; KOG1818; Eukaryota.
DR GeneTree; ENSGT00390000016097; -.
DR HOGENOM; CLU_020922_0_0_1; -.
DR OMA; RYTHQYD; -.
DR OrthoDB; 277036at2759; -.
DR TreeFam; TF323237; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005776; C:autophagosome; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0097629; C:extrinsic component of omegasome membrane; IEA:Ensembl.
DR GO; GO:0005795; C:Golgi stack; IEA:Ensembl.
DR GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0000407; C:phagophore assembly site; IEA:Ensembl.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:Ensembl.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:Ensembl.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009267; P:cellular response to starvation; IEA:Ensembl.
DR GO; GO:0140042; P:lipid droplet formation; IEA:Ensembl.
DR GO; GO:0016236; P:macroautophagy; IEA:Ensembl.
DR GO; GO:0044829; P:positive regulation by host of viral genome replication; IEA:Ensembl.
DR CDD; cd19819; Bbox1_ZFYVE1_rpt1; 1.
DR CDD; cd19820; Bbox1_ZFYVE1_rpt2; 1.
DR CDD; cd15734; FYVE_ZFYV1; 1.
DR CDD; cd01851; GBP; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR042427; ZFYV1.
DR InterPro; IPR047856; ZFYVE1_first_BBox1.
DR InterPro; IPR047855; ZFYVE1_second_BBox1.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46624; AGAP002036-PA; 1.
DR PANTHER; PTHR46624:SF3; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF01363; FYVE; 2.
DR SMART; SM00064; FYVE; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS50178; ZF_FYVE; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 13..63
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 40..69
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 602..663
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 719..779
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
SQ SEQUENCE 781 AA; 87719 MW; C1B4081B0A90C640 CRC64;
MSAHAPLVEK GLNTALMCQE SYVCSGTDEA VFECDECGSL QCQRCEEELH RQERLRNHER
TRIRPGHVPY CDNCKGANGN IMHSNTTGSR QRAAMRCQMC KTNLCMECQK RTHTGGNKRK
HTITMYHGSK PQEEEEEGMD EETKRKKMTE KVASFLLVDE TEEIQVMNED DFIKKLDCKP
DQHLKVVSIF GNTGDGKSHT LNHTFFYGRE VFKTSPAQES CTVGVWAAYD PVHKVVVIDT
EGLLGATVNV SQRTRLLLKV LAISDLVIYR TRADRLHNDL FKFLGDASEA YLKHFTKELK
ATTARCGLDV PLSTLGPAVI IFHETVYTKL LGSDHPSEAP EKLIQDRFRK LSRFPEAFSS
IHYKGTRTYN PPTDFSGLRR AVEHQLENNT TRSPRQPGVI FKALKALSDR FSGEIPDDQM
AHSSFFPDEY FTCSSVCFSC GCGCKNSMNH AKEGAPHEAK SRCRYSHQYD NRVYTCKACY
ERGKEVSVVP KTSASTDSPW MGLAKYAWSG YVIECPNCGV VYRSRQYWFG NQDPVDTVVR
TEIEHVWPGT DGFLKDNNNA AQRLLDGMNF MAQSVSELSL GPTKAVTSWL TDQIAPAYWR
PNSQILNCNK CGTSFKENDT KHHCRACGEG FCDGCSSKTR PVPERGWGPA PVRVCDDCYD
SRGIQLDVPE AQTEEEGGTL IARKVGEAVQ NTLGAVVTAI DIPLGLVKDA ARPAYWVPDH
EILQCHNCQK EFNIKLSKHH CRACGQGFCD ECSNERRAVP SRGWDHPVRV CFNCNKKPGD
L
//
