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Database: UniProt
Entry: K7FFT4_PELSI
LinkDB: K7FFT4_PELSI
Original site: K7FFT4_PELSI 
ID   K7FFT4_PELSI            Unreviewed;       962 AA.
AC   K7FFT4;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   05-JUN-2019, entry version 55.
DE   RecName: Full=Metalloendopeptidase {ECO:0000256|RuleBase:RU361183};
DE            EC=3.4.24.- {ECO:0000256|RuleBase:RU361183};
GN   Name=BMP1 {ECO:0000313|Ensembl:ENSPSIP00000006894};
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae;
OC   Pelodiscus.
OX   NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000006894, ECO:0000313|Proteomes:UP000007267};
RN   [1] {ECO:0000313|Ensembl:ENSPSIP00000006894}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17381049; DOI=10.1080/10425170600760091;
RA   Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.;
RT   "The complete mitochondrial genome of the Korean soft-shelled turtle
RT   Pelodiscus sinensis (Testudines, Trionychidae).";
RL   DNA Seq. 17:471-483(2006).
RN   [2] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG   Soft-shell Turtle Genome Consortium;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPSIP00000006894}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR001199-2,
CC         ECO:0000256|RuleBase:RU361183};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR001199-
CC       2, ECO:0000256|RuleBase:RU361183};
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; AGCU01168945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01168946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01168947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01168948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01168949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01168950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01168951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01168952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01168953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 13735.ENSPSIP00000006894; -.
DR   Ensembl; ENSPSIT00000006933; ENSPSIP00000006894; ENSPSIG00000006192.
DR   eggNOG; KOG3714; Eukaryota.
DR   eggNOG; ENOG410ZPX7; LUCA.
DR   GeneTree; ENSGT00940000157176; -.
DR   OMA; KGFEASH; -.
DR   TreeFam; TF314351; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0061036; P:positive regulation of cartilage development; IEA:Ensembl.
DR   CDD; cd00041; CUB; 5.
DR   CDD; cd04281; ZnMc_BMP1_TLD; 1.
DR   Gene3D; 2.60.120.290; -; 5.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR029837; BMP-1.
DR   InterPro; IPR015446; BMP_1/tolloid-like.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001506; Peptidase_M12A.
DR   InterPro; IPR006026; Peptidase_Metallo.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR034036; ZnMP_TLD/BMP1.
DR   PANTHER; PTHR45645:SF24; PTHR45645:SF24; 1.
DR   Pfam; PF01400; Astacin; 1.
DR   Pfam; PF00431; CUB; 5.
DR   Pfam; PF07645; EGF_CA; 1.
DR   PIRSF; PIRSF001199; BMP_1/tolloid-like; 1.
DR   PRINTS; PR00480; ASTACIN.
DR   SMART; SM00042; CUB; 5.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00235; ZnMc; 1.
DR   SUPFAM; SSF49854; SSF49854; 5.
DR   PROSITE; PS00010; ASX_HYDROXYL; 2.
DR   PROSITE; PS01180; CUB; 5.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007267};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00438935};
KW   Hydrolase {ECO:0000256|RuleBase:RU361183,
KW   ECO:0000256|SAAS:SAAS00973787};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001199-2,
KW   ECO:0000256|RuleBase:RU361183, ECO:0000256|SAAS:SAAS00973795};
KW   Metalloprotease {ECO:0000256|RuleBase:RU361183,
KW   ECO:0000256|SAAS:SAAS01068076};
KW   Protease {ECO:0000256|RuleBase:RU361183,
KW   ECO:0000256|SAAS:SAAS00973825};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW   Repeat {ECO:0000256|SAAS:SAAS00792548};
KW   Zinc {ECO:0000256|PIRSR:PIRSR001199-2, ECO:0000256|RuleBase:RU361183,
KW   ECO:0000256|SAAS:SAAS00973802}.
FT   DOMAIN      297    409       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      410    522       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      522    563       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      566    679       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      679    719       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      723    835       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      836    952       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   REGION       36    100       Disordered. {ECO:0000256|MobiDB-lite:
FT                                K7FFT4}.
FT   COMPBIAS     80     97       Basic. {ECO:0000256|MobiDB-lite:K7FFT4}.
FT   ACT_SITE    189    189       {ECO:0000256|PIRSR:PIRSR001199-1}.
FT   METAL       188    188       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR001199-2}.
FT   METAL       192    192       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR001199-2}.
FT   METAL       198    198       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR001199-2}.
SQ   SEQUENCE   962 AA;  108688 MW;  FF62C044CD3C0C7E CRC64;
     CFPVAFLGDI ALDEEDLKLF QLDQLADLRR RTFEKPANTT SGGIKGRCKK GAPDPTLPGN
     GEHNTGPGAP GISTSLAARR QRKRQWRQVR SRSRRAATSR HERVWPDGVI PYVISGNFSG
     SQRAIFRQAM RHWEKHTCVT FLERNTEESY IVFTHRPCGC CSYVGHRGGG PQAISIGKNC
     DKFGIVVHEL GHVIGFWHEH TRPDRDDHVS IVRENIQPGQ EYNFLKMEPE EVESLGETYD
     FDSIMHYARN TFSRGVFLDT IKPKYSVNGV VPHIGQRTRL SKGDIDQARK LYRCPACGET
     LQDSQGNFSS PEFPNGYPAH MHCIWRISVT PGEKIILNFT TMDLYRSRLC WYDYVEVRDG
     FWRKATQRGR FCGNKLPEPI ISTDSRLWIE FRSSSNWVGK GFFAVYEAIC GGEMKKDNGH
     IQSPNYPDEY RPNKVCTWKI TISEGYHVGL TFQSFEIERH DSCAYDYLEI RDGSTESSSL
     IGRYCGYDKP DDIKSTSNKL WMKFVSDGSI NKAGFAVNFF KEVDECSQAN NGGCEQRCVN
     TLGSYRCACD PGYELALDKR RCEAACGGLL TRLNGSITSP GWPKEYPPNK DCVWHLVAPS
     QYRISLQFEF FETEGNDQVC KYDFVEVRSG LSADSKLHGK FCGAEKPEVI TSQYNNMRIE
     FKSDNTVSKK GFKAHFFSDK DECSKDNGGC QHDCLNTFGS YQCQCRSGFV LHDNKHDCKE
     AGCDHKVTSI TGTITSPNWP DKYPSKKECT WAITTTPGHR VKLTFTELDV EGHQECTYDH
     LEVYNGKDAK APVLGRFCGA KEPDPVVSTG NKLFLKFFSD NSVQKKGFQA TYSTVCGGQL
     RAEVKTKDLY SHAQFGDNNY PGGSDCEWVI VAEEGYGVEL IFQTFEIEEE ADCGYDYIEL
     FDGYDGTAPR LGRYCGSGPP EEVCSAGDSV MIKFHSDDTI NKKGFHLRYT STKFQDTLHS
     RK
//
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