ID K7FFU4_PELSI Unreviewed; 361 AA.
AC K7FFU4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=NIPA magnesium transporter 2 {ECO:0000313|Ensembl:ENSPSIP00000006904.1};
GN Name=NIPA2 {ECO:0000313|Ensembl:ENSPSIP00000006904.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000006904.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000006904.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NIPA family.
CC {ECO:0000256|ARBA:ARBA00007230}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGCU01170656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01170657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006135883.1; XM_006135821.2.
DR RefSeq; XP_006135884.1; XM_006135822.2.
DR RefSeq; XP_006135885.1; XM_006135823.2.
DR RefSeq; XP_006135886.1; XM_006135824.2.
DR RefSeq; XP_014435379.1; XM_014579893.1.
DR STRING; 13735.ENSPSIP00000006896; -.
DR Ensembl; ENSPSIT00000006935.1; ENSPSIP00000006896.1; ENSPSIG00000006334.1.
DR Ensembl; ENSPSIT00000006943.1; ENSPSIP00000006904.1; ENSPSIG00000006334.1.
DR GeneID; 102450457; -.
DR KEGG; pss:102450457; -.
DR CTD; 81614; -.
DR eggNOG; KOG2922; Eukaryota.
DR GeneTree; ENSGT00940000155651; -.
DR HOGENOM; CLU_012349_1_1_1; -.
DR OMA; PMVYISI; -.
DR OrthoDB; 53219at2759; -.
DR TreeFam; TF313214; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.3730.20; -; 1.
DR InterPro; IPR008521; Mg_trans_NIPA.
DR PANTHER; PTHR12570:SF1; MAGNESIUM TRANSPORTER NIPA2; 1.
DR PANTHER; PTHR12570; UNCHARACTERIZED; 1.
DR Pfam; PF05653; Mg_trans_NIPA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 361 AA; 39098 MW; A9B7561CC6B10818 CRC64;
MIQSGGKYDF YIGLVLAMSS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG HAYLKEWLWW
AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS SYFLNEKLNL HGKIGCLLSV
LGSTVMVIHA PQEEEVETLN EMSHKLGDPG FVVFATLVVI VSLILIFVVG PRHGQTNILV
YITICSVIGA LSVSCVKGLG ITIKELFSGK PVLKHPLSWI LLLSLIVCVS TQINYLNRAL
DIFNTSIVTP IYYVFFTTSV LTCSAILFKE WQHMSAADII GTFSGFLTII VGIFLLHAFK
DVSFTLANLP VSLRKDDRAV NGTLPATYEC FNHNEESSTC ISEIQSSESV SSRRNGNLAA
F
//
